INT178257

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.25
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
adipose tissue 4
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 89.84 High High
melanocortin 1 receptor 22 61.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 138 96.92 Very High Very High Very High
Obesity 66 96.76 Very High Very High Very High
Syndrome 14 93.36 High High
Hyperphagia 4 80.12 Quite High
Hyperinsulinism 14 79.60 Quite High
Hyperplasia 10 46.68 Quite Low
Hyperglycemia 8 39.56 Quite Low
Hypertrophy 2 37.44 Quite Low
Insulin Resistance 2 36.24 Quite Low
Diabetes Mellitus 22 35.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice with adipocyte-specific agouti expression were shown to have significantly increased fat mass compared to control mice, which was accompanied by an increase in the protein levels of three transcription factors (Pparg, peroxisome proliferator activated receptor gamma; Stat1, signal transducer and activator of transcription 1; and Stat3) in their adipose tissue [36].
Positive_regulation (increase) of Transcription (transcription) of Pparg in adipose tissue associated with targeted disruption and obesity
1) Confidence 0.49 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.12 Pain Relevance 0.11
Transgenic mice with adipocyte-specific agouti expression were shown to have significantly increased fat mass compared to control mice, which was accompanied by an increase in the protein levels of three transcription factors (Pparg, peroxisome proliferator activated receptor gamma; Stat1, signal transducer and activator of transcription 1; and Stat3) in their adipose tissue [36].
Positive_regulation (increase) of Transcription (transcription) of peroxisome proliferator activated receptor gamma in adipose tissue associated with targeted disruption and obesity
2) Confidence 0.33 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.14 Pain Relevance 0.11

General Comments

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