INT17826

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 39
Total Number 41
Disease Relevance 11.35
Pain Relevance 10.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pla2g1b) extracellular region (Pla2g1b)
Anatomy Link Frequency
mesangial cells 5
brain 2
nucleus pulposus 2
neurons 2
intervertebral discs 2
Pla2g1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 69 100.00 Very High Very High Very High
Inflammatory response 10 100.00 Very High Very High Very High
Kinase C 4 100.00 Very High Very High Very High
Substantia gelatinosa neuron 6 99.92 Very High Very High Very High
COX2 6 99.86 Very High Very High Very High
substantia gelatinosa 4 99.68 Very High Very High Very High
dorsal root ganglion 1 99.68 Very High Very High Very High
Sciatica 8 99.32 Very High Very High Very High
ischemia 6 99.32 Very High Very High Very High
Glutamate 4 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 106 100.00 Very High Very High Very High
Cancer 34 100.00 Very High Very High Very High
Cv Unclassified Under Development 6 99.32 Very High Very High Very High
Nerve Root Compression 5 99.32 Very High Very High Very High
Ganglion Cysts 4 99.20 Very High Very High Very High
Pain 70 99.16 Very High Very High Very High
Hyperalgesia 49 99.02 Very High Very High Very High
Leukemia 1 98.80 Very High Very High Very High
Nociception 6 98.12 Very High Very High Very High
Nephrotoxicity 5 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was suggested that opiates cause a formation of the potassium carrier in mitochondria by releasing Ca2+, which activate phospholipase A2.
Positive_regulation (activate) of phospholipase A2 associated with opiate
1) Confidence 0.70 Published 1980 Journal Biokhimiia Section Abstract Doc Link 7378487 Disease Relevance 0 Pain Relevance 0.60
Fluoxetine, a selective serotonin reuptake inhibitor, selectively increased incorporation of arachidonic acid by increasing 5-HT availability in the synaptic cleft and thus indirectly activating phospholipase A2.
Positive_regulation (activating) of phospholipase A2 in synaptic cleft associated with ssri and fluoxetine
2) Confidence 0.67 Published 2003 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 12928041 Disease Relevance 0 Pain Relevance 0.23
Considering that the substantia gelatinosa plays an important role in regulating nociceptive transmission, it is suggested that this transmission may be positively modulated by secreted phospholipase A2 activation in the substantia gelatinosa.
Positive_regulation (activation) of phospholipase A2 in substantia gelatinosa associated with nociception and substantia gelatinosa
3) Confidence 0.65 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.10 Pain Relevance 0.22
We conclude that melittin increases the spontaneous release of L-glutamate to substantia gelatinosa neurons by activating secreted phospholipase A2 and increasing Ca2+ influx through voltage-gated Ca2+ channels in nerve terminals, probably with an involvement of arachidonic acid but not its metabolites produced by cyclooxygenase and lipoxygenase.
Positive_regulation (activating) of phospholipase A2 in neurons associated with glutamate and substantia gelatinosa neuron
4) Confidence 0.65 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.08 Pain Relevance 0.26
In animal studies, it has been shown that hyperalgesia (an increased sensitivity to painful stimuli) involves activation of phospholipase A2 and nitric oxide synthase.
Positive_regulation (activation) of phospholipase A2
5) Confidence 0.54 Published 1996 Journal Spine Section Body Doc Link 8893434 Disease Relevance 0.08 Pain Relevance 0
STUDY DESIGN: The possible role of phospholipase A2 in an animal model for lumbar radiculopathy and mechanisms of epidural steroid injections were studied.
Spec (possible) Positive_regulation (role) of phospholipase A2 associated with epidural and sciatica
6) Confidence 0.50 Published 1998 Journal Spine Section Abstract Doc Link 9636970 Disease Relevance 0.17 Pain Relevance 0.22
The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat.
Positive_regulation (role) of phospholipase A2 in intervertebral disc associated with pain and sciatic nerve
7) Confidence 0.50 Published 1997 Journal Spine Section Title Doc Link 9160464 Disease Relevance 0.10 Pain Relevance 0.24
However, it is not known what the relation is between the hyperalgesia produced and the activation and involvement of phospholipase A2 and production of nitric oxide, or why the application of nucleus pulposus and nucleus pulposus with anulus fibrosus produces different types of hyperalgesia.
Positive_regulation (activation) of phospholipase A2 in nucleus pulposus
8) Confidence 0.50 Published 1997 Journal Spine Section Body Doc Link 9160464 Disease Relevance 0.06 Pain Relevance 0
The authors suggest that chemical mediators such as phospholipase A2 and nitric oxide, induced by extruded or sequestrated intervertebral discs, are involved in the pathophysiologic mechanisms of painful radiculopathy in lumbar disc herniations.
Positive_regulation (induced) of phospholipase A2 in intervertebral discs associated with pain and sciatica
9) Confidence 0.50 Published 1998 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9646768 Disease Relevance 0.71 Pain Relevance 0.94
Bilateral ligation with ketamine as general anesthetic resulted in a rapid, transient increase in phospholipase A2 activity.
Positive_regulation (increase) of phospholipase A2 associated with ketamine
10) Confidence 0.50 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7119783 Disease Relevance 0.31 Pain Relevance 0.24
Imaging of brain serotonergic neurotransmission involving phospholipase A2 activation and arachidonic acid release in unanesthetized rats.
Positive_regulation (activation) of phospholipase A2 in brain associated with imagery
11) Confidence 0.49 Published 2003 Journal Brain Res. Brain Res. Protoc. Section Title Doc Link 12928041 Disease Relevance 0 Pain Relevance 0.19
In vitro studies have shown that 5-HT2 receptors can be coupled via G-proteins to phospholipase A2 (PLA2) activation, releasing arachidonic acid from phospholipids.
Positive_regulation (activation) of phospholipase A2
12) Confidence 0.49 Published 2003 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 12928041 Disease Relevance 0 Pain Relevance 0.07
The increase in intracellular cAMP concentration in rat mesangial cells and the inhibition by CGP 28238 of phosphodiesterase 4 activity with an IC50 value of 23 muM gave a rationale to explain the underlying mechanisms for the induction of the inflammatory response genes COX-2, soluble phospholipase A2 and inducible NO synthase in rat mesangial cells.
Positive_regulation (induction) of phospholipase A2 in mesangial cells associated with inflammatory response
13) Confidence 0.48 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9495802 Disease Relevance 0.17 Pain Relevance 0.16
In rat mesangial cells, CGP 28238 induced the mRNA and the protein of COX-2 as well as those of inducible nitric oxide synthase and soluble phospholipase A2.
Positive_regulation (induced) of phospholipase A2 in mesangial cells
14) Confidence 0.48 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9495802 Disease Relevance 0.16 Pain Relevance 0.19
On the induction of cyclooxygenase-2, inducible nitric oxide synthase and soluble phospholipase A2 in rat mesangial cells by a nonsteroidal anti-inflammatory drug: the role of cyclic AMP.
Positive_regulation (induction) of phospholipase A2 in mesangial cells associated with inflammation, cinod and cox2
15) Confidence 0.48 Published 1998 Journal Mol. Pharmacol. Section Title Doc Link 9495802 Disease Relevance 0.19 Pain Relevance 0.27
In the preparation with the submucosal plexus, quinacrine and indomethacin completely blocked the effect of melittin, indicating activation of phospholipase A2 and production of prostaglandins induced by the drug.
Positive_regulation (activation) of phospholipase A2
16) Confidence 0.45 Published 1991 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1944607 Disease Relevance 0 Pain Relevance 0.11
Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation.
Positive_regulation (Time-course) of phospholipase A2 associated with inflammation
17) Confidence 0.44 Published 1993 Journal Int. J. Immunopharmacol. Section Title Doc Link 8375942 Disease Relevance 0.52 Pain Relevance 0.48
Activation of ethanolamine phospholipase A2 in Brain during ischemia.
Positive_regulation (Activation) of phospholipase A2 in Brain associated with ischemia
18) Confidence 0.43 Published 1982 Journal J. Neurochem. Section Title Doc Link 7119783 Disease Relevance 0.33 Pain Relevance 0.24
Alterations in lipids were associated with up-regulation of phospholipase A2.
Positive_regulation (up-regulation) of phospholipase A2
19) Confidence 0.37 Published 2005 Journal Arch. Toxicol. Section Abstract Doc Link 15889237 Disease Relevance 0.19 Pain Relevance 0.24
Various physiological stimuli activate phospholipase A2 and release arachidonic acid, which is converted to 1 or 2 products by related enzymes within a few minutes, depending upon individual cell functions.
Positive_regulation (activate) of phospholipase A2
20) Confidence 0.37 Published 1989 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 2509310 Disease Relevance 0.23 Pain Relevance 0.14

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