INT178260

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 3.09
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
Melanocytes 2
pigmentation 2
liver 1
tail 1
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 327 99.80 Very High Very High Very High
agonist 24 92.40 High High
Central nervous system 2 54.32 Quite High
Kinase C 5 30.00 Quite Low
antagonist 13 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 149 99.56 Very High Very High Very High
Freckles 51 98.88 Very High Very High Very High
Syndrome 14 97.04 Very High Very High Very High
Hyperplasia 10 88.16 High High
Hyperinsulinism 14 86.36 High High
Obesity 67 85.84 High High
Hyperglycemia 8 85.64 High High
Hyperphagia 4 75.04 Quite High
Body Weight 26 73.60 Quite High
Hypertrophy 2 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intracellular E3 ubiquitin ligase mahogunin (MGRN1) also seems crucial: Mgrn1md-nc homozygous mice likewise lack any pigmentary response to ASIP (He et al., 2003).
Positive_regulation (response) of ASIP
1) Confidence 0.50 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.06 Pain Relevance 0.04
Melanocytes genetically null for ASIP mediators attractin or mahogunin (Atrnmg-3J/mg-3J or Mgrn1md-nc/md-nc) also responded to both ASIP and ASIP-YY in cAMP level, while only ASIP altered their proliferation and (in part) shape.
Positive_regulation (mediators) of ASIP in Melanocytes
2) Confidence 0.50 Published 2009 Journal Pigment Cell & Melanoma Research Section Abstract Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.20
A carboxy-terminal fragment of ASIP: lack of effect on cell number, shape or pigmentation of melan-a cells
Positive_regulation (fragment) of ASIP in pigmentation
3) Confidence 0.44 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.09
Attractin is required for ASIP effects in the mouse, and was suggested to function to enhance ASIP–MC1R binding (Barsh, 2006).
Positive_regulation (required) of ASIP associated with melanocortin 1 receptor
4) Confidence 0.44 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.18
To investigate molecular requirements for the ASIP effects, immortal melanocytes were isolated carrying the null mutations Atrnmg-3J (melan-mg1 and -2) and Mgrn1md-nc (melan-md1 and -2).
Spec (investigate) Positive_regulation (requirements) of ASIP in melanocytes
5) Confidence 0.44 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.05
For the two major QTLs, the derived Agouti and Mc1r alleles increase the average coat reflectance (i.e., produce lighter color) and reduce the extent of dorsal, rump, and tail pigmentation (Table 1), changes consistent with the idea that these alleles were fixed by natural selection in beach mice.
Positive_regulation (derived) of Agouti in tail associated with melanocortin 1 receptor
6) Confidence 0.42 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.55
To identify whether a coding change in the Agouti gene itself might also contribute to the pigmentation differences between our subspecies, we sequenced Agouti's three translated exons (encoding a 139 amino acid protein) in the six original parents of our cross (Figure S2).
Positive_regulation (change) of Agouti in pigmentation
7) Confidence 0.42 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.57
The ability of agouti to antagonize binding of ?
Positive_regulation (ability) of agouti
8) Confidence 0.39 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.18 Pain Relevance 0.12
For this purpose, we generated lines of transgenic mice expressing high levels of agouti in the liver under the regulatory control of the albumin promoter.
Positive_regulation (levels) of agouti in liver associated with targeted disruption
9) Confidence 0.39 Published 2004 Journal Mol Cancer Section Abstract Doc Link PMC443512 Disease Relevance 1.13 Pain Relevance 0.22
Here we uncover the molecular variation that causes melanism in P. maniculatus from New Hampshire and show that the Agouti gene is responsible.
Positive_regulation (responsible) of Agouti associated with freckles
10) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.72 Pain Relevance 0.06

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