INT178262

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.73
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
adipose tissue 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 100 99.08 Very High Very High Very High
cytokine 75 98.70 Very High Very High Very High
chemokine 23 90.68 High High
Multiple sclerosis 48 90.32 High High
Central nervous system 4 88.24 High High
Bioavailability 2 85.84 High High
aspirin 2 80.36 Quite High
rheumatoid arthritis 88 74.36 Quite High
melanocortin 1 receptor 22 59.72 Quite High
Arthritis 26 35.08 Quite Low
Disease Link Frequency Relevance Heat
Obesity 66 99.12 Very High Very High Very High
INFLAMMATION 99 99.08 Very High Very High Very High
Disease 99 98.50 Very High Very High Very High
Targeted Disruption 142 96.12 Very High Very High Very High
Inflammatory Bowel Disease 78 96.12 Very High Very High Very High
Syndrome 14 91.76 High High
Colitis 38 90.68 High High
Multiple Sclerosis 57 90.32 High High
Hyperphagia 4 78.52 Quite High
Hyperinsulinism 14 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using in vivo and in vitro models, we have measured effects of PEO on disease activity index, histological parameters, and changes in proinflammatory cytokine levels as well as changes in expression and activation of a key transcription factor, Signal Transducer and Activator of Transcription (STAT1).
Transcription (transcription) of STAT1 associated with disease and cytokine
1) Confidence 0.59 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.76 Pain Relevance 0.25
Transgenic mice with adipocyte-specific agouti expression were shown to have significantly increased fat mass compared to control mice, which was accompanied by an increase in the protein levels of three transcription factors (Pparg, peroxisome proliferator activated receptor gamma; Stat1, signal transducer and activator of transcription 1; and Stat3) in their adipose tissue [36].
Transcription (transcription) of Stat1 in adipose tissue associated with targeted disruption and obesity
2) Confidence 0.54 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.13 Pain Relevance 0.10
The disease attenuation by PEO is likely associated with suppression of activation of STAT1 transcription and inhibition of pro-inflammatory cytokines.



Transcription (transcription) of STAT1 associated with inflammation, disease and cytokine
3) Confidence 0.46 Published 2010 Journal BMC Chem Biol Section Abstract Doc Link PMC2881005 Disease Relevance 0.66 Pain Relevance 0.28
This included transcripts for IL-8, IL-17 receptor, STAT1, and TRAIL.
Transcription (transcripts) of STAT1
4) Confidence 0.32 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.04 Pain Relevance 0.38
Transgenic mice with adipocyte-specific agouti expression were shown to have significantly increased fat mass compared to control mice, which was accompanied by an increase in the protein levels of three transcription factors (Pparg, peroxisome proliferator activated receptor gamma; Stat1, signal transducer and activator of transcription 1; and Stat3) in their adipose tissue [36].
Transcription (transcription) of signal transducer and activator of transcription 1 in adipose tissue associated with targeted disruption and obesity
5) Confidence 0.24 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.14 Pain Relevance 0.10

General Comments

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