INT178264

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.52
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc4r) plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
hypothalamus 2
spinal cord 2
Mc4r (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.68 Very High Very High Very High
melanocortin 1 receptor 81 92.64 High High
Central nervous system 32 91.12 High High
Potency 30 88.24 High High
medulla 54 85.12 High High
vagus nerve 14 82.80 Quite High
antagonist 37 82.08 Quite High
Neuropathic pain 7 81.00 Quite High
Neuropeptide 8 79.64 Quite High
agonist 107 75.84 Quite High
Disease Link Frequency Relevance Heat
Obesity 229 99.12 Very High Very High Very High
Sprains And Strains 21 99.08 Very High Very High Very High
Hyperphagia 8 98.86 Very High Very High Very High
Hyperinsulinism 7 98.60 Very High Very High Very High
Injury 18 98.28 Very High Very High Very High
Targeted Disruption 97 94.60 High High
Syndrome 13 82.96 Quite High
Neuropathic Pain 22 81.00 Quite High
Overweight 6 80.88 Quite High
Nervous System Injury 2 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mc4r ko mice, or lethal yellow mice overexpressing agouti, NPY expression (but not galanin or POMC) is significantly elevated in the DMH.
Positive_regulation (elevated) of Gene_expression (overexpressing) of mc4r
1) Confidence 0.43 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.07 Pain Relevance 0.08
In mc4r ko mice, or lethal yellow mice overexpressing agouti, NPY expression (but not galanin or POMC) is significantly elevated in the DMH.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of mc4r
2) Confidence 0.43 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.07 Pain Relevance 0.08
-MSH sequestered MC4R in a dose-dependent manner (maximal sequestration, ?
Positive_regulation (sequestered) of Gene_expression (sequestered) of MC4R
3) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0 Pain Relevance 0.07
These results suggest that the hyperinsulinemia, hyperphagia, and obesity in lethal yellow and viable yellow mice is caused primarily by agouti-induced antagonism of Mc4r in the hypothalamus, a center of autonomic regulatory control in the brain [35].
Positive_regulation (caused) of Gene_expression (antagonism) of Mc4r in hypothalamus associated with hyperphagia, obesity and hyperinsulinism
4) Confidence 0.40 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.45 Pain Relevance 0.12
The expression of MC4R has been shown to increase in the spinal cord after peripheral nerve-injury [47].
Positive_regulation (increase) of Gene_expression (expression) of MC4R in spinal cord associated with injury and spinal cord
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 1.13 Pain Relevance 1.01
HEK293 cells transiently transfected with wild-type or mutant MC4R were stimulated with increasing concentrations of ?
Positive_regulation (transfected) of Gene_expression (transfected) of MC4R
6) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0.08 Pain Relevance 0.04
Alternatively, retrovirus-mediated hypothalamic expression of RM1 and Rm2 in adult MC4R-deficient mice could be used as a first step in evaluating Rm1 and Rm2 in vivo.
Positive_regulation (mediated) of Gene_expression (expression) of MC4R
7) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0.49 Pain Relevance 0
HEK293 cells transiently transfected with wild-type or mutant MC4R were stimulated with increasing concentrations of ?
Positive_regulation (stimulated) of Gene_expression (transfected) of MC4R
8) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0.09 Pain Relevance 0.04
HEK293 cells transiently transfected with wild-type or mutant MC4R were stimulated with increasing concentrations of ?
Positive_regulation (stimulated) of Gene_expression (type) of MC4R
9) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0.09 Pain Relevance 0.04
-MSH elicited full activation of wild-type MC4R (EC50?
Positive_regulation (activation) of Gene_expression (type) of MC4R
10) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1930153 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox