INT178291

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 39
Disease Relevance 8.20
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Hps1) cytoplasmic membrane-bounded vesicle (Hps1)
Anatomy Link Frequency
hippocampus 7
oocytes 6
granulosa cell 3
cumulus cell 1
embryos 1
Hps1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 114 99.60 Very High Very High Very High
agonist 154 99.40 Very High Very High Very High
alcohol 70 94.36 High High
Potency 45 88.56 High High
imagery 41 79.44 Quite High
long-term potentiation 16 77.40 Quite High
Pain 38 76.80 Quite High
cva 2 71.04 Quite High
Spinal cord 12 64.84 Quite High
medulla 11 64.20 Quite High
Disease Link Frequency Relevance Heat
Hantavirus Infection 29 100.00 Very High Very High Very High
Targeted Disruption 367 99.72 Very High Very High Very High
Heart Rate Under Development 112 99.54 Very High Very High Very High
Cancer 382 94.56 High High
Amyloid Plaque 38 94.48 High High
Down Syndrome 96 92.36 High High
Alzheimer's Dementia 160 86.60 High High
Neurodegenerative Disease 41 86.40 High High
Arrhythmias 2 Under Development 210 84.36 Quite High
Heart Disease 30 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven species in the virus family Bunyaviridae, genus Hantavirus (1), have been causally associated with HPS: Sin Nombre virus (SNV), New York virus (NYV), Black Creek Canal virus (BCCV), Bayou virus (BAYV), and Choclo virus (CHOV) in North America (2–6), and Andes virus (ANDV) and Laguna Negra virus (LANV) in South America (7,8).
Gene_expression (virus) of HPS in Canal associated with hantavirus infection
1) Confidence 0.67 Published 2007 Journal Emerging Infectious Diseases Section Body Doc Link PMC2725987 Disease Relevance 0.72 Pain Relevance 0
The occurrence of the lesions is accelerated in the mouse when a hPS1 gene with exon 9 deleted (line S9) is coexpressed with a hAPP gene with the APP Swedish mutation (line C3-3), yielding an APPswe/PS1dE9 line [100, 191].
Gene_expression (coexpressed) of hPS1
2) Confidence 0.58 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.81 Pain Relevance 0.04
Quantitative evaluation of expression levels revealed that expression of three HPs was deranged in hemizygous and homozygous SOD1-TGs: Expression levels of 2610008O03Rik protein (Q9D0K2) and 4632432E04Rik protein (Q9D358) were significantly decreased in SOD1-TG hippocampus while Hypothetical protein (Q99KP6) was significantly decreased (Fig. 2 and Table 2).
Gene_expression (expression) of HPs in hippocampus associated with hippocampus
3) Confidence 0.25 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0 Pain Relevance 0.13
Most HPs were represented by strong spots and the present study shows that they are indeed expressed in mouse hippocampus.
Gene_expression (represented) of HPs in hippocampus associated with hippocampus
4) Confidence 0.25 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0 Pain Relevance 0.08
The aim of this study was to search for the existence of hypothetical proteins (HPs), that have been identified based upon their nucleic acid sequences only and resulted in the detection of 14 HPs and significant expressional differences of HPs related to metabolism, signaling and the transcriptional machinery were observed in hippocampus of the SOD1-TG.
Gene_expression (expressional) of HPs in hippocampus associated with hippocampus
5) Confidence 0.25 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.52 Pain Relevance 0.24
The aim of this study was to search for the existence of hypothetical proteins (HPs), that have been identified based upon their nucleic acid sequences only and resulted in the detection of 14 HPs and significant expressional differences of HPs related to metabolism, signaling and the transcriptional machinery were observed in hippocampus of the SOD1-TG.
Gene_expression (detection) of HPs in hippocampus associated with hippocampus
6) Confidence 0.25 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.55 Pain Relevance 0.25
The aim of this study was to search for the existence of hypothetical proteins (HPs), that have been identified based upon their nucleic acid sequences only and resulted in the detection of 14 HPs and significant expressional differences of HPs related to metabolism, signaling and the transcriptional machinery were observed in hippocampus of the SOD1-TG.
Gene_expression (detection) of HPs in hippocampus associated with hippocampus
7) Confidence 0.25 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.52 Pain Relevance 0.24
The aim of this study was to search for the existence of hypothetical proteins (HPs), that have been identified based upon their nucleic acid sequences only and resulted in the detection of 14 HPs and significant expressional differences of HPs related to metabolism, signaling and the transcriptional machinery were observed in hippocampus of the SOD1-TG.
Gene_expression (detection) of HPs in hippocampus associated with hippocampus
8) Confidence 0.25 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.53 Pain Relevance 0.24
We herein provided a series of HPs that were predicted from nucleic sequences only, to exist and expressed in mouse hippocampus and the list of these proteins is contributing by adding new structures to cascades and pathways.
Gene_expression (expressed) of HPs in hippocampus associated with hippocampus
9) Confidence 0.22 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.26 Pain Relevance 0.12
Aberrant expression of some HPs may help to understand proteinchemical changes in the SOD1-TG hippocampus, which in turn may allow insight into pathomechanisms of mental deficits in the SOD1-TG per se but probably also in DS brain.


Gene_expression (expression) of HPs in brain associated with down syndrome and hippocampus
10) Confidence 0.22 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.31 Pain Relevance 0.12
Because no data are available on the kinetics of placental transfer of EP, only data on placental transfer of E2 can be used for comparison.
Gene_expression (transfer) of EP
11) Confidence 0.13 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.14 Pain Relevance 0
Mural cells are well established as expressing multiple EP receptors.
Gene_expression (expressing) of EP
12) Confidence 0.11 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
It is possible that cumulus cell expression of EP receptors changes in response to the midcycle LH surge, which may explain discrepancies between these studies.
Gene_expression (expression) of EP in cumulus cell
13) Confidence 0.11 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
To determine if monkey oocytes express functional EP receptors, GV stage oocytes stripped of cumulus granulosa cells were cultured with PGE2, the EP2 receptor agonist butaprost, or the EP4 receptor agonist PGE1 alcohol.
Spec (determine) Gene_expression (express) of EP in oocytes associated with agonist and alcohol
14) Confidence 0.11 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.23
Similarly, expression and function of EP receptors in mouse oocytes were examined (not shown).
Gene_expression (expression) of EP in oocytes
15) Confidence 0.11 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.05
For EP only, the 10,000 ?
Gene_expression (For) of EP
16) Confidence 0.11 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.31 Pain Relevance 0
From measurements taken after mice pregnant with transgenic embryos were exposed to DES and EP, it was possible to evaluate the ability of the in vivo model to detect well-known estrogens in embryos exposed in utero.
Gene_expression (exposed) of EP in embryos associated with targeted disruption
17) Confidence 0.11 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.10 Pain Relevance 0
In contrast, only 8 hr after EP exposure (10,000 ?
Gene_expression (exposure) of EP
18) Confidence 0.11 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.06 Pain Relevance 0
Aromatase mRNA was not detected in any of the 6 oocyte preparations (not shown), indicating that granulosa cell contamination was not responsible for detection of EP mRNAs in monkey oocytes.
Gene_expression (detection) of EP in granulosa cell
19) Confidence 0.10 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Immunofluorescent detection of EP receptors
Gene_expression (receptors) of EP
20) Confidence 0.10 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0

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