INT178300

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 4.85
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Hps3) cytoplasm (Hps3)
Anatomy Link Frequency
blood 1
Hps3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 12 84.04 Quite High
Pain 11 65.24 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 250 99.48 Very High Very High Very High
Coagulation Disorder 180 98.80 Very High Very High Very High
Abscess 630 98.76 Very High Very High Very High
Bacteremia 100 96.92 Very High Very High Very High
Infection 150 93.60 High High
Staphylococcus Infection 150 89.44 High High
Death 40 89.08 High High
Shock 10 76.36 Quite High
Akathisia 10 75.60 Quite High
Volume Depletion And Dehydration 10 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When probed for expression of coagulases with specific antibodies, we observed Coa secretion by wild-type S. aureus as well as the ?
Gene_expression (expression) of coa
1) Confidence 0.75 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.61 Pain Relevance 0
Coagulase production is used as a diagnostic test, differentiating S. aureus isolates from commensal staphylococci, for example S. epidermidis [18].
Gene_expression (production) of Coa
2) Confidence 0.75 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.53 Pain Relevance 0
For the coagulase-fibrinogen interaction, coagulase was injected at 100 pM, 500 pM, 1 nM, 5 nM, 10 nM, 25 nM, 50 nM, 100 nM, and 300 nM for 60 seconds of association followed by 60 seconds of dissociation and the chip was regenerated as described above.
Gene_expression (injected) of coa
3) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0
Measurements of coagulase activity
Gene_expression (activity) of coa
4) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0
In contrast, deletion of both coagulase genes caused a dramatic defect; ?
Gene_expression (deletion) of coa
5) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.76 Pain Relevance 0
Introduction of pvWbp-coa, a plasmid providing for the expression of both coagulase genes, into ?
Gene_expression (expression) of coa
6) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.59 Pain Relevance 0
For the coagulase-fibrinogen interaction, coagulase was injected at 100 pM, 500 pM, 1 nM, 5 nM, 10 nM, 25 nM, 50 nM, 100 nM, and 300 nM for 60 seconds of association followed by 60 seconds of dissociation and the chip was regenerated as described above.
Gene_expression (injected) of coa
7) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0 Pain Relevance 0
Antibodies against coagulases affect staphylococcal clotting of blood
Gene_expression (Antibodies) of coa in blood associated with coagulation disorder
8) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.67 Pain Relevance 0
DNA sequences 1 kb upstream and downstream of coa and vWbp were PCR amplified using the primers attB1_Coa, Coa1_BamHI, Coa2_BamHI, attbB2_Coa and attB1_vWF, vWF1_BamHI, vWF2_BamHI, attbB2_vWF (Table S1).
Gene_expression (using) of Coa
9) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.84 Pain Relevance 0.07
DNA sequences 1 kb upstream and downstream of coa and vWbp were PCR amplified using the primers attB1_Coa, Coa1_BamHI, Coa2_BamHI, attbB2_Coa and attB1_vWF, vWF1_BamHI, vWF2_BamHI, attbB2_vWF (Table S1).
Gene_expression (using) of Coa
10) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.84 Pain Relevance 0.07
2610008O03Rik protein (Q9D0K2) has two conserved domains, coenzyme A (CoA) transferases (pfam01144) (Fig. 3), and belongs to an evolutionary conserved family of enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another.
Gene_expression (transfer) of CoA
11) Confidence 0.01 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox