INT178301

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.96
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
precursor cells 1
brain 1
stomach 1
Egf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 91.12 High High
Central nervous system 12 66.60 Quite High
Hippocampus 49 62.72 Quite High
cINOD 24 59.12 Quite High
monoamine 39 58.20 Quite High
chemokine 4 44.40 Quite Low
cytokine 22 43.56 Quite Low
Inflammation 36 37.36 Quite Low
fibrosis 4 30.36 Quite Low
Pyramidal cell 9 5.48 Low Low
Disease Link Frequency Relevance Heat
Stress 15 100.00 Very High Very High Very High
Targeted Disruption 357 99.14 Very High Very High Very High
Metastasis 7 98.24 Very High Very High Very High
Sprains And Strains 128 97.36 Very High Very High Very High
Cancer 308 93.44 High High
Ulcers 66 93.20 High High
Apoptosis 14 90.68 High High
Neurodegenerative Disease 21 88.16 High High
Congenital Anomalies 27 76.24 Quite High
Hepatocellular Cancer 47 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In comparison, Omez altered the EGF level much less.
Regulation (altered) of EGF
1) Confidence 0.58 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.48 Pain Relevance 0.06
These modifications combined the gradient enrichment procedure originally described for rat hippocampal precursor cells with the addition of both EGF and FGF2, the use of B27 as the serum supplement, the control of appropriate plating densities, and the optional use of additional exogenous factors for the trophic support of the cultured cells.
Regulation (control) of EGF in precursor cells
2) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0
On the other hand, we did not detect significant differences between controls and KO mice regarding the relative expression of other EGF family growth factors, such as EGF [Control; 100±4.58 (mean±S.E.M., n?
Regulation ([Control) of EGF associated with targeted disruption
3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.01 Pain Relevance 0.06
Down-regulation of EGF receptor signaling, induced by mutation of the Hb-egf gene, could affect synaptic plasticity by regulating NDMA relating proteins, and this would lead to the abnormal behaviors observed in HB-EGF KO mice.
Regulation (regulation) of EGF associated with targeted disruption
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.44 Pain Relevance 0.06
On the other hand, we did not detect significant differences between controls and KO mice regarding the relative expression of other EGF family growth factors, such as EGF [Control; 100±4.58 (mean±S.E.M., n?
Regulation (other) of EGF associated with targeted disruption
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.99 Pain Relevance 0.06
The present study was undertaken to evaluate the potential of the rhizomes of the Indian medicinal plant, Picrorhiza kurroa in healing indomethacin-induced acute stomach ulceration in mice and examine its capacity to modulate oxidative stress and the levels of prostaglandin (PGE2) and EGF during the process.


Spec (examine) Regulation (modulate) of EGF in stomach associated with stress
6) Confidence 0.26 Published 2008 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2266895 Disease Relevance 0.10 Pain Relevance 0
Several genes exhibiting strain-dependent differences in prostate expression have been studied in the context of prostate development (for example, Sbp), androgen regulation (Fabp5, Odc), tumorigenesis (for example, Psca, Azgp1, Apod, Mmp7, Egf, Mgst1, Clusterin), and the progression of metastatic cancer (Cxcl12, B2m, H2 family members) [8].
Regulation (regulation) of Egf associated with sprains and strains and metastasis
7) Confidence 0.17 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.99 Pain Relevance 0.03
To confirm the importance of huMSC-secreted EGF and IL-6 on Skov-3 cell proliferation, we co-cultured huMSC and rLuc/RFP labeled Skov-3 in vitro and immunoprecipitated (IP) EGF and/or IL-6 out of solution (individually and in combination).
Regulation (importance) of EGF
8) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.34 Pain Relevance 0
There is also participation in the transcriptional regulation of growth factors such as EGF through JNK activation [61].
Regulation (regulation) of EGF
9) Confidence 0.10 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.43 Pain Relevance 0
The enzyme also dephosphorylates EGF receptors in bovine brain suggesting that it may be involved in modulation of EGF signaling in the nerve tissue [34].
Regulation (modulation) of EGF in brain
10) Confidence 0.10 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.17 Pain Relevance 0.05

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