INT178330

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.39
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1)
Pon1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 27 81.16 Quite High
Disease Link Frequency Relevance Heat
Atherosclerosis 27 99.28 Very High Very High Very High
Coronary Artery Disease 216 99.20 Very High Very High Very High
Disorder Of Lipid Metabolism 21 94.00 High High
Targeted Disruption 3 89.92 High High
Cv General 3 Under Development 21 81.16 Quite High
Disease 33 72.24 Quite High
Diabetes Mellitus 21 25.00 Low Low
Renal Disease 9 25.00 Low Low
Hyperlipidemia 12 5.00 Very Low Very Low Very Low
Myocardial Infarction 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since LDL oxidation is importantly linked to atherosclerosis a genetic factor that had a direct effect on PON1 activity should therefore be associated with CHD.
Regulation (effect) of PON1 associated with coronary artery disease and atherosclerosis
1) Confidence 0.62 Published 2004 Journal BMC Genet Section Body Doc Link PMC449704 Disease Relevance 1.11 Pain Relevance 0
Since lipid levels vary between the sexes the antioxidant effect of PON1 and any genes associated with it may also vary by sex.
Regulation (effect) of PON1
2) Confidence 0.27 Published 2004 Journal BMC Genet Section Abstract Doc Link PMC449704 Disease Relevance 0.57 Pain Relevance 0
There are two known polymorphisms in the PON1 gene and two in the PON2 gene all of which could plausibly influence PON1 activity and hence CHD risk [13].
Regulation (influence) of PON1 associated with coronary artery disease
3) Confidence 0.27 Published 2004 Journal BMC Genet Section Body Doc Link PMC449704 Disease Relevance 0.71 Pain Relevance 0.08

General Comments

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