INT178338

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 50
Total Number 50
Disease Relevance 38.65
Pain Relevance 12.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbx15) DNA binding (Tbx15)
Anatomy Link Frequency
brain 4
nerve 4
neurons 3
dorsal horn 2
embryos 1
Tbx15 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 129 99.84 Very High Very High Very High
Dorsal horn neuron 19 99.84 Very High Very High Very High
Dorsal horn 56 99.78 Very High Very High Very High
metalloproteinase 18 99.76 Very High Very High Very High
Central nervous system 31 99.68 Very High Very High Very High
spinal dorsal horn 35 99.66 Very High Very High Very High
Neuropathic pain 234 99.52 Very High Very High Very High
Inflammation 170 99.44 Very High Very High Very High
dorsal root ganglion 159 99.36 Very High Very High Very High
Spinal cord 139 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Porphyria 76 100.00 Very High Very High Very High
Aids-related Complex 463 99.84 Very High Very High Very High
Injury 115 99.84 Very High Very High Very High
Nervous System Injury 186 99.82 Very High Very High Very High
Disease 441 99.70 Very High Very High Very High
Nociception 240 99.64 Very High Very High Very High
Metastasis 183 99.56 Very High Very High Very High
Neuropathic Pain 355 99.52 Very High Very High Very High
INFLAMMATION 174 99.44 Very High Very High Very High
Ganglion Cysts 171 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neurotrophin, brain-derived neurotrophic factor (BDNF), is a major
Gene_expression (neurotrophic) of de in brain
1) Confidence 0.65 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.54 Pain Relevance 0.19
, tumour necrosis factor-alpha, inducible nitric-oxide synthase, and MMPs [14].
Gene_expression (synthase) of de associated with necrosis, cancer and metalloproteinase
2) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 1.13 Pain Relevance 0.38
Other metabolic or protein synthesis enzymes were identified as aspartyl-tRNA synthetase (two spots), D-3-phosphoglycerate dehydrogenase, prolyl 4-hydroxylase beta polypeptide, alpha-enolase (three spots) and gamma-enolase, all of which were more highly expressed in neuroma, whereas pyruvate kinase isozyme M2, cytosolic non-specific dipeptidase, lactate dehydrogenase B chain and carbonic anhydrase 3 (two spots) were expressed at a lower level.


Gene_expression (expressed) of de associated with neuroma
3) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.54 Pain Relevance 0
Tanaka et al reported that protein disulfide isomerase is up-regulated in response to hypoxia/brain ischemia in glial cells [29], whilst increased protein disulfide isomerase expression has been shown to be neuroprotective in the rat hippocampal CA1 region [31].


Gene_expression (expression) of de in glial cells associated with brain hemorrhage, hypoxia and ischemia
4) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.61 Pain Relevance 0.05
DNMT3a and DNMT3b have equal preferences for hemi-methylated and non-methylated DNA, and so have been classified as de novo methyltransferases [8].
Gene_expression (methyltransferases) of de
5) Confidence 0.14 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1131894 Disease Relevance 0.30 Pain Relevance 0
In vivo de novo prions
Gene_expression (prions) of de novo
6) Confidence 0.04 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2950034 Disease Relevance 0.53 Pain Relevance 0
This view was supported by the recent finding that nerve injury-induced neuropathic pain is associated with the de novo synthesis of LPA, which is produced by a conversion of lysophosphatidylcholine (LPC) through autotaxin (ATX) or lysophospholipase D (lysoPLD) [11,12].
Gene_expression (synthesis) of de novo in nerve associated with nervous system injury and neuropathic pain
7) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2599895 Disease Relevance 1.34 Pain Relevance 0.72
The ensuing irreversible PGHS inhibition requires de novo synthesis of the enzyme for subsequent production of prostaglandins.
Gene_expression (synthesis) of de novo
8) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1592475 Disease Relevance 0.31 Pain Relevance 0.71
However, Marmigere et al. [35] showed that virally expressed Runx1 induced de novo synthesis of TrkA in the DRG and spinal cord of chick embryos.
Gene_expression (synthesis) of de novo in embryos associated with dorsal root ganglion and spinal cord
9) Confidence 0.03 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.74 Pain Relevance 0.25
In Ngf-Bax compound knockout DRG, TrkA neurons are hypotrophic although de novo Runx1 expression is unaffected [42].
Gene_expression (expression) of de novo in neurons associated with targeted disruption and dorsal root ganglion
10) Confidence 0.03 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.66 Pain Relevance 0.21
Regarding the proposal that LPA involved in the dorsal root demyelination comes from the spinal dorsal horn, we have reported that the intense stimulation of spinal dorsal horn in vitro causes de novo production of LPA [29].
Gene_expression (production) of de novo in dorsal horn associated with demyelination and spinal dorsal horn
11) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.15 Pain Relevance 0.90
The present study demonstrated that LPA1 receptor signaling following injury causes demyelination specifically at the dorsal root, which is consistent with de novo LPA production.
Gene_expression (production) of de novo in dorsal root associated with demyelination and injury
12) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.38 Pain Relevance 0.76
These amino acids (leucine, isoleucine, and valine) cannot be synthesized de novo but must be obtained from dietary sources and have a unique role in amino acid metabolism, regulating the intra- and interorgan exchange of nitrogen and amino acids by different tissues [91].
Gene_expression (synthesized) of de novo
13) Confidence 0.02 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3017957 Disease Relevance 0.76 Pain Relevance 0
Despite their lack of involvement in synapse phagocytosis, microglia rapidly respond to the presence of synaptic degeneration with increased or de novo expression of different proteins and a change in morphology (Rao and Lund, 1993; Jensen et al., 1999).
Gene_expression (expression) of de novo in microglia
14) Confidence 0.02 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.20 Pain Relevance 0.04
Because no significant nociceptive threshold change was observed in uninjured LPA1-null mice, it is evident that de novo LPA, produced by injury, is involved in the generation of a neuropathic pain state.
Gene_expression (produced) of de novo associated with nociception, injury and neuropathic pain
15) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.65 Pain Relevance 1.04
Altogether, we propose a hypothesis for mechanisms of neuropathic hyperalgesia and allodynia after partial sciatic nerve injury (Fig. 6) as follows: 1) intense stimulation of sensory neurons after sciatic nerve injury activates target neurons in the dorsal horn to induce de novo biosynthesis of LPC, which is in turn converted to LPA by ATX/LPLD; 2) LPA is then produced at the dorsal root fibers proximal to the spinal cord.
Gene_expression (biosynthesis) of de novo in sciatic nerve associated with hyperalgesia, nervous system injury, allodynia, neuropathic pain, dorsal horn, sciatic nerve and spinal cord
16) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.10 Pain Relevance 0.98
Nerve injury-induced de novo LPA biosynthesis
Gene_expression (biosynthesis) of de novo in Nerve associated with nervous system injury
17) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.71 Pain Relevance 1.04
The most well-studied relates to metabotropic glutamate receptor-dependent long term depression (mGluR-LTD) in hippocampal CA1 neurons that normally requires de novo protein synthesis in dendrites.
Gene_expression (synthesis) of de novo in neurons associated with depression and glutamate receptor
18) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.85 Pain Relevance 0.32
We found that Arc/Arg3.1 is not present in naïve or vehicle treated animals, and is de novo expressed in dorsal horn neurons after nociceptive stimulation.
Gene_expression (expressed) of de novo in neurons associated with nociception, aids-related complex and dorsal horn neuron
19) Confidence 0.02 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2920254 Disease Relevance 1.44 Pain Relevance 0.72
However, after peripheral nociceptive stimulation we found de novo expression of Arc/Arg3.1 in a limited number of neurons in the superficial dorsal horn, depending on the type of stimulus.
Gene_expression (expression) of de novo in dorsal horn associated with nociception, aids-related complex and dorsal horn
20) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.49 Pain Relevance 0.73

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