INT178339

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.14
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
liver 2
neutrophil 2
lymph nodes 1
leukocytes 1
erythrocytes 1
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 80 100.00 Very High Very High Very High
antagonist 23 99.80 Very High Very High Very High
Inflammation 265 99.36 Very High Very High Very High
tolerance 48 98.20 Very High Very High Very High
cytokine 91 94.04 High High
Bioavailability 11 87.36 High High
isoflurane 6 68.68 Quite High
ketamine 5 66.44 Quite High
Arthritis 6 63.52 Quite High
fibrosis 12 58.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 260 99.36 Very High Very High Very High
Apoptosis 40 98.20 Very High Very High Very High
Infection 54 96.44 Very High Very High Very High
Crystal Associated Disease 75 90.96 High High
Francisella Infection 58 88.40 High High
Acute-phase Reaction 2 88.28 High High
Sprains And Strains 41 88.16 High High
Lung Injury 48 88.08 High High
Necrosis 8 85.72 High High
Cancer 11 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multiplex bead immunoassay (Lincoplex) was performed according to the manufacturer's protocol on the Luminex 100 platform to measure concentrations of KC/CXCL1, MCP-1/CCL2, MIP-1?
CXCL1 Binding (concentrations) of
1) Confidence 0.36 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.07 Pain Relevance 0.19
CXCR2 is the shared cellular receptor for the murine CXC chemokine ligands KC/CXCL1 and MIP-2/CXCL2/3 [18-20].
KC/CXCL1 Binding (ligands) of associated with chemokine
2) Confidence 0.27 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.26 Pain Relevance 0.15
(CXCL1), bind to the receptor CXCR2 to promote neutrophil chemotaxis and can also affect angiogenesis.
CXCL1 Binding (bind) of in neutrophil
3) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.07 Pain Relevance 0.40
as well as chemokine (C-X-C motif) ligands IP-10 (Cxcl10), KC (Cxcl1), and MCP-1 (Ccl2).
Cxcl1 Binding (ligands) of associated with chemokine
4) Confidence 0.22 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.43 Pain Relevance 0.14
These data point to the potential need for development of novel antagonists of CXCR1, CXCR2 or their ligands CXCL1 and CXCL8.
CXCL1 Binding (ligands) of associated with antagonist
5) Confidence 0.21 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.47 Pain Relevance 0.33
In rodents, neutrophils recognize at least 2 chemokines (KC and macrophage inflammatory protein-2, MIP-2) that are synthesized de novo in response to gram-negative bacteria or LPS in the lungs, and each is independently essential to maximal neutrophil recruitment [2-4].
KC Binding (recognize) of in neutrophils associated with chemokine and inflammation
6) Confidence 0.08 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.26 Pain Relevance 0.13
Thus, a realistic kinetic scheme should also include three ATP-bound states, as shown below (Colquhoun, 1998):(SCHEME 2)where KO is the equilibrium binding constant for ATP binding to intraburst states (O, CF) and KC is the equilibrium binding constant for ATP binding to the interburst long closed states (CS).
KC Binding (binding) of
7) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2442177 Disease Relevance 0 Pain Relevance 0
This immunoregulatory ability of KC is dramatically increased following liver transplantation, especially in KC recovered from chronically accepted liver allografts.
KC Binding (ability) of in liver
8) Confidence 0.06 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.15 Pain Relevance 0.10
Donor Lewis hepatic KC replacement by recipient DA KC following liver transplantation results in increased FasL expression by KC in the liver allografts.
KC Binding (recipient) of in liver
9) Confidence 0.06 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.14
KC, which comprise one of major populations (20%) of the hepatic nonparenchymal cell fraction (NPC), can directly interact with passenger leukocytes and thus may play a role in immunomodulation and the induction of tolerance [7].
KC Binding (interact) of in leukocytes associated with tolerance
10) Confidence 0.06 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.33 Pain Relevance 0.21
Following liver transplantation, donor KC not only migrate into the recipient lymph nodes, but also can be quickly replaced by recipient-derived monocytes [8,9].
KC Binding (migrate) of in lymph nodes
11) Confidence 0.06 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.34 Pain Relevance 0.19
The fact that the IC50 for ATP inhibition of macroscopic currents through 4M channels was also increased indicates that the K185E mutation also reduces the affinity of ATP binding to the long closed states (KC).
KC Binding (binding) of
12) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2442177 Disease Relevance 0 Pain Relevance 0
Since ATP is a KATP channel antagonist, it must bind with higher affinity to the interburst closed state (Cs in Scheme 2) than to the open state (KC > KO).
KC Binding (bind) of associated with antagonist
13) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2442177 Disease Relevance 0 Pain Relevance 0.05
Thus, a realistic kinetic scheme should also include three ATP-bound states, as shown below (Colquhoun, 1998):(SCHEME 2)where KO is the equilibrium binding constant for ATP binding to intraburst states (O, CF) and KC is the equilibrium binding constant for ATP binding to the interburst long closed states (CS).
KC Binding (binding) of
14) Confidence 0.05 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2442177 Disease Relevance 0 Pain Relevance 0
In a study to compare binding and internalization of free, soluble chains and particles (1 micrometer) of chondroitin sulphate (CS) it was found that LSEC but not KC bound and internalized the soluble form of CS.
KC Binding (bound) of
15) Confidence 0.02 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.13 Pain Relevance 0.03
Cultured KC and LSEC both avidly bind IgG-coated erythrocytes [15].
KC Binding (bind) of in erythrocytes
16) Confidence 0.02 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.12 Pain Relevance 0
In contrast to LSEC, only KC internalized the bound red cells, reflecting the general principle that KC perform phagocytosis of particles >1 micrometer, whereas LSEC internalize only nm size colloids or truly soluble macromolecules.


KC Binding (bound) of
17) Confidence 0.02 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.32 Pain Relevance 0

General Comments

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