INT17834

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Context Info
Confidence 0.26
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 3.37
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
Coronary artery 2
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 1 95.88 Very High Very High Very High
Angina 4 76.08 Quite High
headache 1 57.48 Quite High
Inflammatory marker 3 54.56 Quite High
Pain 1 41.88 Quite Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 27 99.68 Very High Very High Very High
Coronary Artery Disease 13 98.68 Very High Very High Very High
Syndrome 9 96.48 Very High Very High Very High
Hemorrhage 1 95.88 Very High Very High Very High
Hematoma 2 94.16 High High
Brain Injury 1 92.40 High High
Cv General 3 Under Development 4 76.08 Quite High
Myocardial Infarction 1 75.32 Quite High
Headache 1 57.48 Quite High
Vomiting 1 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because t-PA antigen levels and PAI-1 activity were highest in the morning, the variation in t-PA activity was probably not due to decreased secretion of t-PA but instead to changes in the secretion of PAI-1.
Negative_regulation (decreased) of Localization (secretion) of t-PA
1) Confidence 0.26 Published 1989 Journal Circulation Section Abstract Doc Link 2491971 Disease Relevance 0.15 Pain Relevance 0.08
There were no significant differences between groups in relevant baseline characteristics apart from significantly higher C-reactive protein levels and reduced net t-PA release in the ACS group at baseline (P < 0.05).
Negative_regulation (reduced) of Localization (release) of t-PA associated with acute coronary syndrome
2) Confidence 0.14 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16014611 Disease Relevance 1.09 Pain Relevance 0.10
Coronary artery disease is associated with impaired endothelium-dependent dilatation and impaired stimulation of t-PA release in the systemic circulation.
Negative_regulation (impaired) of Localization (release) of t-PA in Coronary artery associated with coronary artery disease
3) Confidence 0.10 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16014611 Disease Relevance 0.66 Pain Relevance 0
Although baseline t-PA release was impaired in the ACS patients (0.09 +/- 0.06 compared with 0.39 +/- 0.33 and 0.49 +/- 0.56 ng/ml; P = 0.03), stimulation of t-PA release by ACh and GTN occurred only in the control subjects and not in the ACS or SAP patients.
Negative_regulation (impaired) of Localization (release) of t-PA associated with acute coronary syndrome
4) Confidence 0.10 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16014611 Disease Relevance 0.93 Pain Relevance 0.06
[Intracranial administration of tissue plasminogen activator and its important factors involved concerning the pH and osmotic pressure].
Negative_regulation (pressure) of Localization (administration) of tissue plasminogen activator
5) Confidence 0.02 Published 1991 Journal No Shinkei Geka Section Title Doc Link 1944789 Disease Relevance 0.54 Pain Relevance 0.11

General Comments

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