INT17835

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Context Info
Confidence 0.29
First Reported 1991
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.53
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 12 100.00 Very High Very High Very High
IPN 5 94.72 High High
cva 1 94.32 High High
headache 1 55.92 Quite High
Pain 1 40.32 Quite Low
cytokine 14 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 1 94.32 High High
Hematoma 2 92.60 High High
Brain Injury 1 90.84 High High
Headache 1 55.92 Quite High
Vomiting 1 55.40 Quite High
Increased Venous Pressure Under Development 1 53.72 Quite High
Fever 1 40.72 Quite Low
Pain 1 40.32 Quite Low
Thrombosis 2 33.48 Quite Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of Localization (tissue) of tissue type plasminogen activator associated with metalloproteinase
1) Confidence 0.29 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of Localization (tissue) of tPA associated with metalloproteinase
2) Confidence 0.29 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
Aside from the porous structure, other factors including the content of the crosslinker, PLGA and t-PA could all be varied to regulate t-PA release from the hydrogel.
Regulation (regulate) of Localization (release) of t-PA
3) Confidence 0.25 Published 2001 Journal J Control Release Section Abstract Doc Link 11451495 Disease Relevance 0 Pain Relevance 0.24
[Intracranial administration of tissue plasminogen activator and its important factors involved concerning the pH and osmotic pressure].
Regulation (involved) of Localization (administration) of tissue plasminogen activator
4) Confidence 0.03 Published 1991 Journal No Shinkei Geka Section Title Doc Link 1944789 Disease Relevance 0.53 Pain Relevance 0.10

General Comments

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