INT178391

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.27
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
muscle 1
skeletal muscle 1
A549 1
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 22 99.80 Very High Very High Very High
Inflammatory mediators 13 99.56 Very High Very High Very High
ischemia 27 93.12 High High
cytokine 56 85.56 High High
COX2 29 85.00 Quite High
Inflammation 185 79.28 Quite High
Pain 18 76.12 Quite High
Nerve growth factor 45 72.04 Quite High
intrathecal 10 66.36 Quite High
substance P 9 60.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 208 99.56 Very High Very High Very High
Cancer 174 99.42 Very High Very High Very High
Hemophilus Infection 89 99.32 Very High Very High Very High
Acantholysis 65 98.80 Very High Very High Very High
Apoptosis 76 97.62 Very High Very High Very High
Retinoblastoma 1 96.16 Very High Very High Very High
Bullous Skin Disease 304 95.44 Very High Very High Very High
Cv Unclassified Under Development 25 93.12 High High
Skin Cancer 3 90.80 High High
Breast Cancer 7 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the cellular localization of the p38-dependent inflammatory mediators in LDRG, immunohistochemistry studies were performed for iNOS (Fig. 6A, B, C, D), TNF-?
Spec (determine) Localization (localization) of p38 associated with inflammatory mediators
1) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.38 Pain Relevance 0.54
gene transcription in response to increased contractile activity in skeletal muscle of p38?
Localization (skeletal muscle) of p38 in skeletal muscle
2) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.12 Pain Relevance 0
Thus, muscle-specific deletion of the p38?
Localization (deletion) of p38 in muscle
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.15 Pain Relevance 0
(iv) Study 4: To investigate the location of the action of exogenous NO and of nNOS inhibition in relation to mitoKATP channels and p38MAPK
Localization (relation) of p38MAPK
4) Confidence 0.40 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.52 Pain Relevance 0.15
Western blot analysis was carried out as previously described for phosphorylated and dephosphorylated (total) forms of p38 MAPK and JNK [18], [19].
Localization (forms) of p38 MAPK
5) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.30 Pain Relevance 0.04
To investigate whether p38 MAPK and/or p44/42 MAPK are involved in microglial phagocytosis of A?
Localization (/) of p38 MAPK
6) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0
Herein, we showed that NTHi activated the phosphorylation of p38 MAPK and nuclear translocation of NF-kappa B within 90 mins, and the enhanced DNA binding activity was observed in nuclear extracts of A549 cells after NTHi inoculation.
Localization (translocation) of p38 in A549 associated with hemophilus infection
7) Confidence 0.35 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.14 Pain Relevance 0.12
Prostate apoptosis response (PAR) – 4 appears to supplement JNK activity as loss of this protein caused hyperactivation of NF-kappaB and impairment of JNK and p38 [63].
Neg (impairment) Localization (impairment) of p38 associated with apoptosis
8) Confidence 0.23 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.74 Pain Relevance 0.03
These results demonstrate that p38MAPK is involved in the mechanisms leading to acantholysis and that inhibition of p38MAPK could be a beneficial approach to treat pemphigus patients.
Localization (involved) of p38MAPK associated with acantholysis and bullous skin disease
9) Confidence 0.21 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.02 Pain Relevance 0
Certain signaling aberrations in cancer may promote cytoplasmic HuR localization such as p38 MAPK and PKC pathways.
Localization (localization) of p38 MAPK associated with kinase c and cancer
10) Confidence 0.20 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.91 Pain Relevance 0.09

General Comments

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