INT178399

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.40
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
lung 2
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 75 98.72 Very High Very High Very High
metalloproteinase 9 96.04 Very High Very High Very High
cINOD 4 68.88 Quite High
cytokine 29 67.20 Quite High
chemokine 2 46.24 Quite Low
fibrosis 8 30.36 Quite Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Injury 58 99.98 Very High Very High Very High
Cancer 128 98.88 Very High Very High Very High
INFLAMMATION 78 98.72 Very High Very High Very High
Parkinson's Disease 2 97.68 Very High Very High Very High
Stress 39 95.92 Very High Very High Very High
Melanoma 73 93.00 High High
Metastasis 17 92.28 High High
Apoptosis 95 90.68 High High
Injury 20 84.72 Quite High
Hepatocellular Cancer 94 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined whether VILI affects the activation of JNK1 and p38 MAPK, members of major inflammatory signaling pathways involved in lung injury.
Spec (whether) Regulation (affects) of Spec (whether) Positive_regulation (activation) of JNK1 in lung associated with lung injury and inflammation
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.81 Pain Relevance 0.12
B and JNK study in an animal hepatocarcinogenesis model, regulation of ROS-mediated JNK activation is critical for developing cancer.
Regulation (regulation) of Positive_regulation (activation) of JNK associated with cancer
2) Confidence 0.42 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.56 Pain Relevance 0.05
Regarding gross cellular function in the cell, authors have shown that activation of JNK regulates the cytoskeleton; prevention of nucleosome formation and mitochondrial dysfunction appear to also be major events following JNK activation [59,66,69].
Regulation (regulates) of Positive_regulation (activation) of JNK associated with parkinson's disease
3) Confidence 0.36 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.57 Pain Relevance 0.07
There is also participation in the transcriptional regulation of growth factors such as EGF through JNK activation [61].
Regulation (regulation) of Positive_regulation (activation) of JNK
4) Confidence 0.25 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.43 Pain Relevance 0
Interestingly, the HNE-dependent upregulation of BACE1 expression observed in vitro, appeared to be dependent on the activation of c-jun N-terminal kinases (JNK) and p38MAPK [170].
Regulation (dependent) of Positive_regulation (activation) of JNK
5) Confidence 0.10 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.40 Pain Relevance 0
In addition to caspase inhibition, XIAP has a role in activation of the JNK pathway, with resultant MAP kinase pathway activation, leading to NF-?
Regulation (role) of Positive_regulation (activation) of JNK
6) Confidence 0.07 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.62 Pain Relevance 0

General Comments

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