INT178400

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.61
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Dusp1) nucleoplasm (Dusp1) nucleus (Dusp1)
cell cycle (Dusp1)
Anatomy Link Frequency
lung 2
Dusp1 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 1 100.00 Very High Very High Very High
Inflammation 82 96.40 Very High Very High Very High
cytokine 8 95.88 Very High Very High Very High
chemokine 8 76.56 Quite High
Taxol 2 65.28 Quite High
Inflammatory response 27 63.80 Quite High
Kinase C 10 20.04 Low Low
cINOD 6 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 11 99.82 Very High Very High Very High
Aids-related Complex 71 99.20 Very High Very High Very High
Targeted Disruption 5 96.88 Very High Very High Very High
INFLAMMATION 110 96.40 Very High Very High Very High
Adenocarcinoma 4 96.00 Very High Very High Very High
Reprotox - General 1 78 93.68 High High
Chronic Obstructive Pulmonary Disease 108 92.68 High High
Alzheimer's Dementia 1 89.44 High High
Acute-phase Reaction 2 88.56 High High
Immune System Diseases 2 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The top network in the B6 GMA-SS-exposed lung consisted primarily of decreased gene expression for dual specificity phosphatase 1 (DUSP1), a downregulator of MAPK signaling, transcriptional regulators EGR1, FOS, FOSB, and pro-inflammatory cytokine IL1?
Negative_regulation (decreased) of Gene_expression (expression) of DUSP1 in lung associated with inflammation, aids-related complex and cytokine
1) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.10 Pain Relevance 0.17
A study looking at patients with severe asthma vs nonsevere asthma found a reduction in the dexamethasone-induced expression (messenger RNA) of MKP-1 and elevation in p38 activity in patients with severe asthma compared with patients with nonsevere asthma.92 However, no studies have looked at the GC-mediated induction of MKP-1 in COPD, and consequently no links have yet been made between the expression, activity, or signaling of MKP-1 and the reduction in GC responsiveness in COPD, although the potential is clearly explained.
Negative_regulation (reduction) of Gene_expression (expression) of MKP-1 associated with asthma, chronic obstructive pulmonary disease and dexamethasone
2) Confidence 0.06 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.10 Pain Relevance 0.11
Additionally, JNK activity appears to be inversely related to MKP-1 expression.
Negative_regulation (related) of Gene_expression (expression) of MKP-1
3) Confidence 0.05 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.91 Pain Relevance 0.03
Another study showed that over expression of MKP-1 and DU145 cells blocked the activation of JNK [69].
Negative_regulation (blocked) of Gene_expression (expression) of MKP-1
4) Confidence 0.05 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.50 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox