INT178437

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.69
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8, Jun) nucleus (Mapk8, Jun) mitochondrion (Mapk8)
DNA binding (Jun) cytoplasm (Mapk8) signal transduction (Mapk8)
Anatomy Link Frequency
apoptotic cells 1
nucleus 1
Mapk8 (Mus musculus)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 6 98.20 Very High Very High Very High
cytokine 52 96.28 Very High Very High Very High
Arthritis 54 89.68 High High
ischemia 7 89.16 High High
Inflammation 46 78.40 Quite High
chemokine 7 67.04 Quite High
Kinase C 5 7.32 Low Low
rheumatoid arthritis 33 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 3 99.34 Very High Very High Very High
Apoptosis 27 98.96 Very High Very High Very High
INFLAMMATION 58 97.84 Very High Very High Very High
Osteoporosis 4 95.88 Very High Very High Very High
Myocardial Infarction 26 94.44 High High
Reprotox - General 1 39 92.76 High High
Cancer 23 90.96 High High
Necrosis 6 90.48 High High
Arthritis 64 89.68 High High
Coronary Artery Disease 7 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
JNK is able to activate the transcription factor AP1 [70].
JNK Positive_regulation (activate) of transcription factor AP1
1) Confidence 0.40 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.37 Pain Relevance 0
B to the nucleus and the activation of c-Jun N-terminal kinase (JNK), which leads to the activation of AP-1 [32,33].
JNK Positive_regulation (activation) of AP-1 in nucleus
2) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.91 Pain Relevance 0.36
IR injury activates JNK, and subsequently JNK induces increases in both AP-1 DNA-binding activity and apoptotic cells.
JNK Positive_regulation (increases) of AP-1 in apoptotic cells associated with injury and apoptosis
3) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.41 Pain Relevance 0.22

General Comments

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