INT178440

Context Info Confidence 0.04 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0

cytosol (Map2k4, Mapk14) nucleus (Map2k4, Mapk14) kinase activity (Map2k4, Mapk14) response to stress (Map2k4, Mapk14) cytoplasm (Map2k4, Mapk14) mitochondrion (Mapk14)

Map2k4 (Mus musculus) Mapk14 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 5 5.00 cytokine 2 5.00 adenocard 2 5.00 cINOD 1 5.00 Taxol 1 5.00

Disease Link Frequency Relevance Heat Stress 9 74.72 Reprotox - General 1 39 26.32 Cancer 19 6.88 Apoptosis 25 5.00 Metastasis 6 5.00 Hyperplasia 5 5.00 Hypoxia 3 5.00 Death 3 5.00 Benign Prostatic Hypertrophy 3 5.00 Adenocarcinoma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The interactions between MAP kinase and its immediate upstream kinase (MAPKK) are highly specific: for instance, p42/p44 MAP kinases are phosphorylated solely by MAP/ERK kinase (MEK) 1 and 2; p38 MAP kinase is selectively activated by MAP kinase kinases (MKK) 3 and 6, while JNK is activated by MKK7 and MKK4 in most conditions, however MKK4 can sometimes activate p38 MAP kinase when over expressed.

MKK4 Positive_regulation (activate) of p38

1) Confidence 0.04 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.13 Pain Relevance 0

General Comments

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