INT178445

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4, Mapk8) nucleus (Map2k4, Mapk8) kinase activity (Map2k4, Mapk8)
cytoplasm (Map2k4, Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
Map2k4 (Mus musculus)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 9 69.92 Quite High
Reprotox - General 1 39 28.80 Quite Low
Cancer 19 9.36 Low Low
Apoptosis 25 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Hyperplasia 5 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Benign Prostatic Hypertrophy 3 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interactions between MAP kinase and its immediate upstream kinase (MAPKK) are highly specific: for instance, p42/p44 MAP kinases are phosphorylated solely by MAP/ERK kinase (MEK) 1 and 2; p38 MAP kinase is selectively activated by MAP kinase kinases (MKK) 3 and 6, while JNK is activated by MKK7 and MKK4 in most conditions, however MKK4 can sometimes activate p38 MAP kinase when over expressed.
MKK4 Positive_regulation (activated) of JNK
1) Confidence 0.11 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.13 Pain Relevance 0

General Comments

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