INT178455

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.24
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LIFR) plasma membrane (LIFR)
Anatomy Link Frequency
stage 3 1
LIFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 18 97.84 Very High Very High Very High
cerebral cortex 4 92.60 High High
Hippocampus 63 91.68 High High
long-term potentiation 2 73.32 Quite High
Dopamine 44 30.56 Quite Low
primary somatosensory cortex 50 5.00 Very Low Very Low Very Low
agonist 16 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Neurobehavioral 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 260 100.00 Very High Very High Very High
Premenstrual Syndrome 103 97.84 Very High Very High Very High
Affective Disorder 5 96.16 Very High Very High Very High
Manic Depressive Disorder 3 94.56 High High
Hypothyroidism 4 75.76 Quite High
Coma 1 71.08 Quite High
Aids-related Complex 35 66.04 Quite High
Sleep Initiation And Maintenance Disorders 10 50.00 Quite Low
Restless Legs Syndrome 84 29.68 Quite Low
Stress 6 5.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like migrating sparrows, both depressed and manic patients show reduced latency to REM sleep, loss of SWS, and reduced amounts of total sleep, often with early morning awakening (Benca et al. 1992); sleep decrements are most profound during mania.
Localization (loss) of SWS associated with manic depressive disorder
1) Confidence 0.61 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.47 Pain Relevance 0
Vigilance states were scored in 4-sec epochs using both EEG and behavioral recordings, and categorized as either wakefulness, drowsiness, SWS, or REM sleep.
Localization (sleep) of SWS associated with sleep disorders
2) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.10 Pain Relevance 0
Vigilance states were scored in 4-sec epochs using both EEG and behavioral recordings, and categorized as either wakefulness, drowsiness, SWS, or REM sleep.
Localization (categorized) of SWS associated with sleep disorders
3) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.10 Pain Relevance 0
A significant menstrual cycle variation of stage 3 sleep was observed, and two other studies found decreased SWS or stage 3 sleep during the LP (Table 1).
Localization (sleep) of SWS in stage 3
4) Confidence 0.07 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 1.21 Pain Relevance 0.66
While this model fulfills earlier psychological predictions of separate, sequential mnemonic roles for SWS and REM sleep (Giuditta, 1985; Stickgold, 1998), it is nonetheless controversial whether these states perform distinct mnemonic roles (Hirase et al., 2001; Kudrimoti et al., 1999; Louie and Wilson, 2001; Segawa, 2006; Sejnowski and Destexhe, 2000; Tononi and Cirelli, 2003).
Localization (sleep) of SWS
5) Confidence 0.07 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.07 Pain Relevance 0.17
There is no evidence that SWS inhibits TSH secretion, and the assumption that the decline of TSH values is a permissive condition for the occurrence of SWS seems more logical.
Localization (secretion) of SWS
6) Confidence 0.05 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.31 Pain Relevance 0

General Comments

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