INT178456

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.74
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LIFR) plasma membrane (LIFR)
Anatomy Link Frequency
neurons 2
epithelial cells 2
LIFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 126 100.00 Very High Very High Very High
primary somatosensory cortex 100 100.00 Very High Very High Very High
cerebral cortex 8 84.56 Quite High
cytokine 236 80.84 Quite High
Nerve growth factor 2 73.76 Quite High
Inflammation 52 50.00 Quite Low
long-term potentiation 4 30.80 Quite Low
Inflammatory mediators 32 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 64 99.70 Very High Very High Very High
Sleep Disorders 122 98.70 Very High Very High Very High
Aids-related Complex 70 86.04 High High
Cancer 24 72.96 Quite High
Metaplasia 32 61.96 Quite High
Lung Cancer 64 61.88 Quite High
Genital Human Papilloma Virus 4 56.48 Quite High
INFLAMMATION 84 50.00 Quite Low
Sleep Initiation And Maintenance Disorders 8 50.00 Quite Low
Stress 3 38.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment induced the expression of LIFR?
Positive_regulation (induced) of Gene_expression (expression) of LIFR
1) Confidence 0.50 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.72 Pain Relevance 0.04
Alternatively, the increase in drowsiness occurring during the light phase in migrating sparrows may have compensated for SWS loss during the previous night, thereby accounting for the absence of an increase in SWS-related SWA during the subsequent night.
Positive_regulation (compensated) of Gene_expression (loss) of SWS associated with sleep disorders
2) Confidence 0.41 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.19 Pain Relevance 0
A similar FR901228 treatment of the carcinoma cells further enhanced LIFR expression and LIF-dependent signaling (Fig. 6).
Positive_regulation (enhanced) of Gene_expression (expression) of LIFR associated with carcinoma
3) Confidence 0.36 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.60 Pain Relevance 0.03
Possible mechanisms are genetic and epigenetic changes [1,28] that lead to the inactivation of receptor genes such as silencing LIFR by DNA methylation [29] or enhanced expression of LIFR, OSMR, but reduced expression of IL-6R by acetylation of histone and transcription-controlling factors [22].
Positive_regulation (enhanced) of Gene_expression (expression) of LIFR
4) Confidence 0.36 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.15
LIF receptor (LIFR) expression was induced by treating epithelial cells with growth medium containing 20 nM of the histone deacetylase inhibitor depsipeptide FR901228 (NCI) [22].


Positive_regulation (induced) of Gene_expression (expression) of LIFR in epithelial cells
5) Confidence 0.36 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.12 Pain Relevance 0.07
SWA during SWS was also higher, during the first 4 hours after sleep deprivation, relative to SWA at the same circadian time in baseline.
Positive_regulation (during) of Gene_expression (higher) of SWS associated with sleep disorders
6) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.96 Pain Relevance 0
Next, we compared the mean firing rates of activated neurons in S1, HP, and V1 across WK, SWS, and REM sleep occurring between 2?
Positive_regulation (activated) of Gene_expression (neurons) of SWS in neurons associated with primary somatosensory cortex and hippocampus
7) Confidence 0.04 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.18
Spindle-range LFP activity in itself is certainly not sufficient to induce IEG expression, or else SWS and IS would also lead to IEG upregulation, like REM sleep does.
Positive_regulation (induce) of Gene_expression (expression) of SWS
8) Confidence 0.04 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.16 Pain Relevance 0.07

General Comments

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