INT178457

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 3.98
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LIFR) plasma membrane (LIFR)
Anatomy Link Frequency
stage 1 1
band 1
neural 1
LIFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Locus ceruleus 354 99.00 Very High Very High Very High
Eae 1 98.96 Very High Very High Very High
opiate 21 98.88 Very High Very High Very High
Morphine 10 98.58 Very High Very High Very High
agonist 46 97.60 Very High Very High Very High
Oxycodone 2 93.52 High High
Dismenorea 36 92.88 High High
tramadol 3 92.16 High High
anticonvulsant 1 91.08 High High
Codeine 2 90.48 High High
Disease Link Frequency Relevance Heat
Sleep Disorders 382 99.70 Very High Very High Very High
Manic Depressive Disorder 17 96.40 Very High Very High Very High
Premenstrual Syndrome 206 96.20 Very High Very High Very High
Aids-related Complex 70 95.82 Very High Very High Very High
Cognitive Disorder 129 83.60 Quite High
Opiate Addiction 2 77.44 Quite High
Affective Disorder 17 72.00 Quite High
Akathisia 95 59.36 Quite High
Depression 35 53.00 Quite High
Sleep Initiation And Maintenance Disorders 123 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the marked reduction in sleep during migration, we did not detect a significant increase in SWA during SWS on migratory nights, when compared to the corresponding hours of nonmigratory nights, in the five sparrows recorded during both nonmigratory and migratory states.
Positive_regulation (increase) of SWS
1) Confidence 0.56 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.40 Pain Relevance 0
Alternatively, the increase in drowsiness occurring during the light phase in migrating sparrows may have compensated for SWS loss during the previous night, thereby accounting for the absence of an increase in SWS-related SWA during the subsequent night.
Positive_regulation (increase) of SWS-related associated with sleep disorders
2) Confidence 0.56 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.19 Pain Relevance 0
Although an increase in drowsiness and a corresponding decrease in wakefulness were observed during the day, migrating sparrows did not compensate for sleep loss at night by sleeping more during the day or by increasing SWS intensity on migratory nights.
Positive_regulation (increasing) of SWS associated with sleep disorders
3) Confidence 0.56 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.24 Pain Relevance 0
This may indicate that migrating sparrows respond differently to sleep deprivation or that birds in general, unlike mammals, do not show increases in SWA during SWS following deprivation.
Neg (not) Positive_regulation (increases) of SWS associated with sleep disorders
4) Confidence 0.38 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.43 Pain Relevance 0
Assuming that the decline in 1.25- to 2.5-Hz power in nonmigrating sparrows reflects SWS homeostasis, the apparent absence of an increase in this band during migration suggests that, unlike nonmigrating sparrows, migrating sparrows may require less SWS.
Spec (may) Positive_regulation (require) of SWS in band
5) Confidence 0.38 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.20 Pain Relevance 0
Interestingly, mammals that exhibit large amounts of drowsiness, such as ungulates, typically show reduced quantities of SWS, lending support to the idea that drowsiness can partially compensate for SWS [55].
Positive_regulation (compensate) of SWS associated with sleep disorders
6) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.59 Pain Relevance 0
During drowsiness, EEG activity was intermediate between that of wakefulness and SWS (i.e., increased amplitude in the low-frequency range relative to wakefulness).
Positive_regulation (increased) of SWS associated with sleep disorders
7) Confidence 0.10 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2923628 Disease Relevance 0.27 Pain Relevance 0
With regard to the sedative-hypnotic activity, zopiclone decreases locomotor activity, disrupts rotarod performance, reduces waking, and increases SWS in the rat (Joulou et al 1985; Ueki et al 1987; Carlson et al 2001).
Positive_regulation (increases) of SWS associated with eae
8) Confidence 0.08 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655082 Disease Relevance 0 Pain Relevance 0.21
Indeed, microinjection of morphine directly into the LC has been found to reduce arousal, observed as an increase in SWS [131].
Positive_regulation (increase) of SWS associated with locus ceruleus and morphine
9) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0.17 Pain Relevance 2.39
Comparing the sleep of healthy women at the mid-FP and mid-LP, one study found no significant differences between any sleep parameter (including SE, SOL, REM sleep and SWS) [43], whereas another report detailed significantly decreased REM sleep (%) and significantly increased SWS (%) at the mid-LP compared to the mid-FP [53].
Positive_regulation (increased) of SWS
10) Confidence 0.05 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.24 Pain Relevance 0.18
To the extent that persistent changes in firing rates indicate mnemonic processing (Fuster and Jervey, 1981), and that arc and zif-268 transcriptional upregulation correlates with synaptic remodeling (Guzowski et al., 2000; Jones et al., 2001), our data support the notion that memories produced by novel stimulation during WK are reactivated during SWS and stored during REM sleep, in a two-step consolidation process (Ribeiro and Nicolelis, 2004) otherwise similar to one-step memory reconsolidation (Nader, 2003; Stickgold and Walker, 2005).
Positive_regulation (reactivated) of SWS associated with aids-related complex
11) Confidence 0.04 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.15 Pain Relevance 0.08
Reference [52] Total sleep time, SE (%), SWS (min), and REM sleep (min and %) were increased, whereas SOL (min), ROL (min), WASO, stage 1 sleep (min and %), and stage 2 sleep (%) were decreased.
Positive_regulation (increased) of SWS in stage 1
12) Confidence 0.04 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 1.09 Pain Relevance 0
Hippocampo-cortical reactivation during slow-wave sleep (SWS) (Pavlides and Winson, 1989; Peigneux et al., 2004; Ribeiro et al., 2004; Wilson and McNaughton, 1994) and upregulation during rapid eye movement (REM) sleep of calcium-dependent gene zif-268 (Ribeiro et al., 1999, 2002), a transcription factor (Wisden et al., 1990) with anterograde effects (Petersohn et al., 1995; Thiel et al., 1994) required for the consolidation of several kinds of memory (Bozon et al., 2003; Jones et al., 2001), suggest that the two major sleep states perform complementary mnemonic functions: neural reactivation during SWS and transcriptional storage during REM sleep (Ribeiro and Nicolelis, 2004; Ribeiro et al., 2004).
Positive_regulation (upregulation) of SWS in neural
13) Confidence 0.04 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.04

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