INT178458

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 8.75
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LIFR) plasma membrane (LIFR)
Anatomy Link Frequency
stage 1 2
eye 1
stage 3 1
LIFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 90 99.86 Very High Very High Very High
primary somatosensory cortex 50 97.32 Very High Very High Very High
depression 13 93.44 High High
antidepressant 8 87.44 High High
cytokine 59 84.08 Quite High
sSRI 15 71.68 Quite High
tolerance 14 50.16 Quite High
Inflammation 13 50.00 Quite Low
nud 3 49.72 Quite Low
headache 5 47.92 Quite Low
Disease Link Frequency Relevance Heat
Sleep Disorders 623 100.00 Very High Very High Very High
Premenstrual Syndrome 515 99.86 Very High Very High Very High
Affective Disorder 30 96.16 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 132 95.04 Very High Very High Very High
Manic Depressive Disorder 18 94.56 High High
Depression 63 93.44 High High
Muscle Hypotonia 6 90.64 High High
Stress 19 77.12 Quite High
INFLAMMATION 21 50.00 Quite Low
Dyspepsia 3 49.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This may indicate that migrating sparrows respond differently to sleep deprivation or that birds in general, unlike mammals, do not show increases in SWA during SWS following deprivation.
Negative_regulation (deprivation) of SWS associated with sleep disorders
1) Confidence 0.47 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.43 Pain Relevance 0
Unlike pigeons, however, blackbirds (Turdus merula) did show a decline in SWS-related SWA (0.5- to 4.0-Hz) across the major sleep period, indicating that aspects of mammalian SWS regulation may be present in some birds (Szymczak et al. 1996).
Negative_regulation (decline) of SWS-related
2) Confidence 0.47 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.23 Pain Relevance 0
In addition, a link between the declining trend in 1.25- to 2.5-Hz spectral power and SWS homeostasis in nonmigrating sparrows will need to be established with additional studies of SWS deprivation in both nonmigrating and migrating sparrows.
Negative_regulation (deprivation) of SWS
3) Confidence 0.35 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.31 Pain Relevance 0
Alternatively, the increase in drowsiness occurring during the light phase in migrating sparrows may have compensated for SWS loss during the previous night, thereby accounting for the absence of an increase in SWS-related SWA during the subsequent night.
Negative_regulation (loss) of SWS associated with sleep disorders
4) Confidence 0.35 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.19 Pain Relevance 0
Like migrating sparrows, both depressed and manic patients show reduced latency to REM sleep, loss of SWS, and reduced amounts of total sleep, often with early morning awakening (Benca et al. 1992); sleep decrements are most profound during mania.
Negative_regulation (loss) of SWS associated with manic depressive disorder
5) Confidence 0.35 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.47 Pain Relevance 0
A reduced need for SWS during migration may also be reflected in the shorter REM sleep latencies on migratory nights, since REM sleep latency is positively correlated with SWS need in humans (Feinberg et al. 1992).
Negative_regulation (reduced) of SWS
6) Confidence 0.34 Published 2004 Journal PLoS Biology Section Body Doc Link PMC449897 Disease Relevance 0.20 Pain Relevance 0
Possible mechanisms are genetic and epigenetic changes [1,28] that lead to the inactivation of receptor genes such as silencing LIFR by DNA methylation [29] or enhanced expression of LIFR, OSMR, but reduced expression of IL-6R by acetylation of histone and transcription-controlling factors [22].
Negative_regulation (inactivation) of LIFR
7) Confidence 0.27 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.13
The latency to the first episode of drowsiness decreased significantly during the recovery sleep period, and a trend toward a decrease in the latency to SWS was also observed.
Negative_regulation (decrease) of SWS associated with sleep disorders
8) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.68 Pain Relevance 0
SWA during SWS was also higher, during the first 4 hours after sleep deprivation, relative to SWA at the same circadian time in baseline.
Negative_regulation (deprivation) of SWS associated with sleep disorders
9) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.97 Pain Relevance 0
D: drowsiness; EEG: electroencephalographic; FFT: fast Fourier transform; NREM sleep: non-rapid eye movement sleep; REM sleep: rapid eye movement sleep; SD: sleep deprivation; SWA: slow wave activity; SWS: slow wave sleep; W: wakefulness.


Negative_regulation (deprivation) of SWS in eye associated with sleep disorders
10) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2424059 Disease Relevance 0.35 Pain Relevance 0
Assessment of sleep architecture shows that stage 1 sleep and REM sleep are increased whereas SWS and REM onset latency (REMOL) are reduced in a relatively small number of depressed patients.
Negative_regulation (reduced) of SWS in stage 1
11) Confidence 0.07 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655082 Disease Relevance 0.68 Pain Relevance 0.27
More recently, a study including healthy women and those with PMS found decreased SWS (%) and REM sleep (%) as well as increased stage 2 (%) during the LP in both groups [56].
Negative_regulation (decreased) of SWS associated with dismenorea
12) Confidence 0.05 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.84 Pain Relevance 0.52
In a comparison of “premenstrually symptomatic” women (defined with an increase of at least 30% in the Profile of Mood States questionnaire during the LP) with controls, women experiencing negative mood symptoms during the LP showed decreased SWS (%) at both menstrual phases as well as decreased latency to stage 1 sleep and a trend for increased stage 2 sleep (%) in the LP [46].
Negative_regulation (decreased) of SWS in stage 1
13) Confidence 0.04 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.50 Pain Relevance 0.22
PSG-based studies do not consistently demonstrate disrupted objective sleep in PMDD (see Table 1), though some have shown increased stage 2 sleep and decreases in SWS or REM sleep compared to healthy women [45, 46].
Negative_regulation (decreases) of SWS associated with premenstrual syndrome
14) Confidence 0.04 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.58 Pain Relevance 0.16
A significant menstrual cycle variation of stage 3 sleep was observed, and two other studies found decreased SWS or stage 3 sleep during the LP (Table 1).
Negative_regulation (decreased) of SWS in stage 3
15) Confidence 0.04 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 1.20 Pain Relevance 0.66
Other comparisons of PMS/PMDD women and healthy control women showed patients to have increased stage 2 sleep, decreased REM sleep, or decreased SWS regardless of menstrual phase (Table 2).
Negative_regulation (decreased) of SWS associated with dismenorea and premenstrual syndrome
16) Confidence 0.04 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 1.12 Pain Relevance 0.44
This means that our data are compatible with synaptic downscaling during SWS (Tononi and Cirelli, 2003), as long as downscaling occurs preferentially in non-activated circuits.
Negative_regulation (downscaling) of SWS
17) Confidence 0.04 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.09

General Comments

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