INT17846

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Context Info
Confidence 0.32
First Reported 1991
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.66
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
biliary tract 1
spinal cord 1
skin 1
dorsal root ganglia 1
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 6 100.00 Very High Very High Very High
Inflammation 23 99.76 Very High Very High Very High
Inflammatory response 3 99.22 Very High Very High Very High
Peripheral nerve injury 6 99.04 Very High Very High Very High
cINOD 11 97.28 Very High Very High Very High
Spinal cord 24 96.40 Very High Very High Very High
Pain 2 88.56 High High
anticonvulsant 1 75.68 Quite High
Bile 6 71.28 Quite High
Osteoarthritis 1 68.68 Quite High
Disease Link Frequency Relevance Heat
Cancer 3 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
INFLAMMATION 36 99.76 Very High Very High Very High
Disease 20 99.28 Very High Very High Very High
Nervous System Injury 9 99.04 Very High Very High Very High
Biliary Cancer 5 93.88 High High
Malignant Neoplastic Disease 1 92.88 High High
Increased Venous Pressure Under Development 1 89.96 High High
Pain 2 88.56 High High
Pressure Volume 2 Under Development 1 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since there is little known about the regulation of prostaglandin synthases, the present study was conducted in order to determine the effect of endotoxin treatment on the expression of messenger RNA encoding interleukin 1beta, cyclooxygenase-2, and prostaglandin synthases mediating the formation of prostaglandin E(2) (membrane bound prostaglandin E synthase) and prostaglandin D(2) (lipocalin prostaglandin D synthase) in spinal cord, dorsal root ganglia and skin of rats.
cyclooxygenase-2 Binding (bound) of in skin associated with spinal cord
1) Confidence 0.32 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.08 Pain Relevance 0.26
Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese.
PTGS2 Binding (Association) of associated with cox2 and disease
2) Confidence 0.25 Published 2008 Journal Neurobiol. Aging Section Title Doc Link 17234302 Disease Relevance 0.76 Pain Relevance 0.18
Although the previously reported protective polymorphism (rs20417, -765 G/C) for AD in PTGS2 gene was not polymorphic in the Chinese population, SNPs in both the promoter (-2319 G>T) and 3' region (Ex10+837 T>C) of PTGS2 were associated with the risk of AD (p=0.01 and 0.03, respectively).
PTGS2 Binding (associated) of associated with disease
3) Confidence 0.25 Published 2008 Journal Neurobiol. Aging Section Abstract Doc Link 17234302 Disease Relevance 0.81 Pain Relevance 0.14
Cyclooxygenase exists in two forms: a constitutive form (cyclooxygenase-1) and an inducible form (cyclooxygenase-2), which is associated with inflammation.
cyclooxygenase-2 Binding (associated) of associated with inflammation
4) Confidence 0.25 Published 1998 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 9442367 Disease Relevance 0.94 Pain Relevance 0.47
Since variants in the PTGS2 gene may modify the expression or function of its encoded enzyme to modulate the inflammatory response in the biliary tract, we examined the associations of eight PTGS2 polymorphisms (-645C-->T; Ex3 -8G-->C; IVS5 -275T-->G; IVS7 +111T-->C; Ex10 +127T-->C; Ex10 +686 --->ATTAT-->TTATA; Ex10 +837T-->C; Ex10 -90C-->T) with biliary tract cancer and stones in a population-based case-control study conducted in Shanghai, China.
PTGS2 Spec (examined) Binding (associations) of in biliary tract associated with inflammatory response and biliary cancer
5) Confidence 0.20 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16361272 Disease Relevance 0.88 Pain Relevance 0.51
COX-2: cyclooxygenase-2; SFI: sciatic functional index; CLX: celecoxib; TNF-alpha: tumour necrosis factor alpha; NF-kappaB: nuclear factor kappa b; SD: standard deviation.


cyclooxygenase-2 Binding (deviation) of associated with necrosis and cancer
6) Confidence 0.18 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2607269 Disease Relevance 0.94 Pain Relevance 0.34
Since there is little known about the regulation of prostaglandin synthases, the present study was conducted in order to determine the effect of endotoxin treatment on the expression of messenger RNA encoding interleukin 1beta, cyclooxygenase-2, and prostaglandin synthases mediating the formation of prostaglandin E(2) (membrane bound prostaglandin E synthase) and prostaglandin D(2) (lipocalin prostaglandin D synthase) in spinal cord, dorsal root ganglia and skin of rats.
cyclooxygenase-2 Binding (bound) of in dorsal root ganglia associated with spinal cord
7) Confidence 0.11 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.08 Pain Relevance 0.26
Since there is little known about the regulation of prostaglandin synthases, the present study was conducted in order to determine the effect of endotoxin treatment on the expression of messenger RNA encoding interleukin 1beta, cyclooxygenase-2, and prostaglandin synthases mediating the formation of prostaglandin E(2) (membrane bound prostaglandin E synthase) and prostaglandin D(2) (lipocalin prostaglandin D synthase) in spinal cord, dorsal root ganglia and skin of rats.
cyclooxygenase-2 Binding (bound) of in spinal cord associated with spinal cord
8) Confidence 0.11 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617945 Disease Relevance 0.08 Pain Relevance 0.26
The drugs seemed to interfere with the action of the PG endoperoxide synthase (or PG cyclooxygenase) enzyme resulting in decreased formation of PGG2 and PGH2.
PGH2 Binding (formation) of
9) Confidence 0.08 Published 1991 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 1946560 Disease Relevance 0.08 Pain Relevance 0.04

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