INT178483

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 11.87
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col18a1) extracellular region (Col18a1) cell adhesion (Col18a1)
proteinaceous extracellular matrix (Col18a1) structural molecule activity (Col18a1) extracellular matrix organization (Col18a1)
Anatomy Link Frequency
colon 1
skin 1
Col18a1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 43 100.00 Very High Very High Very High
Somatostatin 1 97.44 Very High Very High Very High
palliative 86 94.36 High High
Multiple sclerosis 103 84.84 Quite High
cytokine 169 82.88 Quite High
anesthesia 18 73.60 Quite High
fibrosis 14 72.16 Quite High
cINOD 2 69.28 Quite High
Inflammation 151 59.56 Quite High
antagonist 17 53.52 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 28 99.88 Very High Very High Very High
Cancer 1477 99.84 Very High Very High Very High
Disease 193 99.60 Very High Very High Very High
Cold Sores 379 99.48 Very High Very High Very High
Systemic Sclerosis 68 99.08 Very High Very High Very High
Colon Cancer 22 97.96 Very High Very High Very High
Skin Cancer 18 95.16 Very High Very High Very High
Metastasis 357 93.60 High High
Breast Cancer 35 92.28 High High
Autoimmune Disease 66 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The produced endostatin was found to inhibit angiogenesis in a human HT29 colon carcinoma model.
Gene_expression (produced) of endostatin in colon associated with colon cancer
1) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.18 Pain Relevance 0
A correlation between disease activity and serum COL18A1 levels has been described in SSc patients in an independent study [103].
Gene_expression (levels) of COL18A1 associated with systemic sclerosis and disease
2) Confidence 0.52 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.96 Pain Relevance 0.19
Interestingly, a correlation between disease activity and serum COL18A1 levels has been described earlier in SSc patients [103].
Gene_expression (levels) of COL18A1 associated with systemic sclerosis and disease
3) Confidence 0.52 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.99 Pain Relevance 0.24
Brideau et al. reported that J4 transgenic mice overexpressing endostatin (driven by the keratin K14 promoter) in epidermal basal cells exhibited inhibited angiogenesis and lymphangiogenesis in skin tumors induced by a carcinogen followed by a tumor promoter agent [16].
Gene_expression (overexpressing) of endostatin in skin associated with targeted disruption, cancer and skin cancer
4) Confidence 0.41 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.21 Pain Relevance 0.03
To evaluate the antimetastatic potential of esVEGFR-2, gene therapy with vector expressing esVEGFR-2 (pesVEGFR-2) or endostatin (pEndo) as a positive control was conducted on murine metastatic mammary cancer.


Gene_expression (expressing) of endostatin associated with cancer
5) Confidence 0.37 Published 2010 Journal BMC Med Section Abstract Doc Link PMC2989928 Disease Relevance 0.81 Pain Relevance 0
Endostatin is a naturally occurring molecule like pesVEGFR-2, not a recombinant protein; hence, we selected endostatin as a positive control.
Gene_expression (selected) of endostatin
6) Confidence 0.36 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.45 Pain Relevance 0
esVEGFR: endogenous soluble vascular endothelial growth factor receptor; H&E: hematoxylin and eosin; LSAB: labeled streptavidin-biotin; MMTV: mouse mammary tumor virus; pEndo: endostatin expression vector; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP-FITC nick end-labeling; VEGF: vascular endothelial growth factor;

Competing interests

Gene_expression (expression) of endostatin associated with cancer
7) Confidence 0.32 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.04 Pain Relevance 0
In fact, endostatin and IL-12 levels were significantly higher in PPAR?
Gene_expression (levels) of endostatin
8) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.91 Pain Relevance 0.06
So far, lentiviral vectors expressing matrix metalloproteinase-2 (MMP-2), angiostatin and endostatin have been developed [136,137].
Gene_expression (expressing) of endostatin associated with metalloproteinase
9) Confidence 0.21 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.73 Pain Relevance 0.05
For example, production of two of the most well known and widely studied angiogenesis inhibitors – angiostatin and endostatin – has recently halted [33].
Gene_expression (production) of endostatin
10) Confidence 0.18 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.62 Pain Relevance 0
However, the alteration of activated tumor MT1-MMP and endostatin levels did not reach statistical significance between the two groups.


Gene_expression (levels) of endostatin associated with cancer
11) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.55 Pain Relevance 0.32
Protein levels of MMP2, TIMP2, VEGF, and endostatin in tumor extracts were measured via commercial available MMP2 (R&D Systems, Minneapolis, MN), TIMP2 (Amersham Biosciences, Buckinghamshire, UK), VEGF enzyme-linked immunosorbent assay (ELISA; R&D Systems, Minneapolis, MN), and endostatin (Chemicon International, Temecula, CA) kits.
Gene_expression (levels) of endostatin associated with cancer
12) Confidence 0.15 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.17 Pain Relevance 0
Recently, targeted angiostatin and endostatin gene transfer [24,25] has been attempted as a means to halt angiogenesis in a mouse tumor model.
Gene_expression (transfer) of endostatin associated with cancer
13) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.66 Pain Relevance 0.08
In vitro growth of these cells was not significantly impacted but subcutaneously implanted tumors were dramatically slowed and a survival advantage was demonstrated in mice given intraperitoneal injections of endostatin-producing clones versus controls.


Gene_expression (producing) of endostatin associated with cancer
14) Confidence 0.14 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.48 Pain Relevance 0
We have previously shown that an engineered antibody containing the anti-laminin L36 scFv and the N-terminal trimerization domain of murine collagen XVIII NC1 was produced in human 293 cells in a functional active form [15].
Gene_expression (produced) of collagen XVIII NC1
15) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670539 Disease Relevance 0.12 Pain Relevance 0.07

General Comments

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