INT178485

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.65
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Cd36) transport (Cd36) mitochondrion (Cd36)
cell adhesion (Cd36) Golgi apparatus (Cd36) plasma membrane (Cd36)
Anatomy Link Frequency
blood 1
stromal cells 1
leukocyte 1
endothelial cell 1
Cd36 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 224 99.80 Very High Very High Very High
Inflammatory mediators 2 93.08 High High
chemokine 10 89.16 High High
cytokine 33 88.56 High High
Bioavailability 2 87.44 High High
glial activation 1 67.40 Quite High
agonist 139 62.24 Quite High
cINOD 56 57.44 Quite High
addiction 5 50.00 Quite Low
metalloproteinase 17 16.12 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 239 99.80 Very High Very High Very High
Apoptosis 132 99.56 Very High Very High Very High
Targeted Disruption 39 98.00 Very High Very High Very High
Cancer 768 96.56 Very High Very High Very High
Immunotherapy Of Cancer 12 91.04 High High
Corneal Neovascularization 7 88.96 High High
Colitis 15 87.24 High High
Carcinoma 21 85.84 High High
Cleidocranial Dysplasia 11 85.24 High High
Hemorrhage 9 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-binding scavenger receptors A (SRA), CD36 and RAGE, and the A?
CD36 Binding (binding) of
1) Confidence 0.22 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.85 Pain Relevance 0.39
A small peptide (ABT510) derived from TSP-1 type 1 repeats binds to CD36 and blocks tumorigenesis by reversing the “angiogenic switch” [229].
CD36 Binding (binds) of
2) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.81 Pain Relevance 0.06
CD36 is expressed in endothelium (small vessels) and a variety of epithelial and stromal cells.(26) Some of the antiangiogenic functions of TSP1 are directly mediated by the binding of TSP1 with CD36.(27) TSP1 also has important functions in inflammation that are dependent of its binding with CD36.(28)
CD36 Binding (dependent) of in stromal cells associated with inflammation
3) Confidence 0.18 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.17 Pain Relevance 0.09
CD36 activation could have consequences in the immune response, favoring leukocyte apoptosis and clearance.(74) In addition, ABT-510 has been proved to induce caspase activation and apoptosis independently of its interaction with CD36.(75)
CD36 Binding (interaction) of in leukocyte associated with apoptosis
4) Confidence 0.18 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.99 Pain Relevance 0.08
More recently, TSP1 has been reported to block the pro-angiogenic effects of nitric oxide (NO) in endothelial and vascular smooth muscle cells.(33) Low level of NO are anti-inflammatory, but in inflamed tissues the levels of NO increase and blood flow, vascular permeability and angiogenesis are enhanced.(11) By interacting with their receptors CD36 and CD47, TSP1 prevents the pro-angiogenic effects of NO and makes EC more susceptible to its inhibition.(33)
CD36 Binding (interacting) of in blood associated with inflammation
5) Confidence 0.17 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.49 Pain Relevance 0.07
TSP-1 is a large molecular weight glycoprotein that inhibits the proliferation and migration of ECs by interacting with CD36 expressed on the cell surface; CD36 is a PPAR?
CD36 Binding (is) of
6) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.11 Pain Relevance 0.03
TSP-1 is a large molecular weight glycoprotein that inhibits the proliferation and migration of ECs by interacting with CD36 expressed on the cell surface; CD36 is a PPAR?
CD36 Binding (interacting) of
7) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.18 Pain Relevance 0.03
These same TSP1 active peptides have been shown to bind to CD36, and neutralizing antibodies to CD36 were able to block native TSP1 and active peptide fragments from inhibition of endothelial cell migration [27].
CD36 Binding (bind) of in endothelial cell
8) Confidence 0.14 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.36 Pain Relevance 0
TSP1 and TSP2 also include, closer to the N-terminal end, three TSP Type 1 repeats (TSR, properdin), which have been implicated in signaling angiogenic inhibition through CD36 binding and support attachment of other cell types [[23,24]; see reviews].
CD36 Binding (binding) of
9) Confidence 0.14 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.35 Pain Relevance 0
Although SR-B1 is known to have broad ligand specificity [15], and recognizes various different lipoprotein classes, we chose unmodified LDL as this particle has shown to bind specifically to SR-B1 but not CD36 or class A scavenger receptors [16].
CD36 Binding (bind) of
10) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0 Pain Relevance 0
The antiangiogenic effects of THBS1 appear to be localized to a peptide sequence containing the type I repeats domain, which binds CD36 on ECs [37].
CD36 Binding (binds) of
11) Confidence 0.12 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.34 Pain Relevance 0.04

General Comments

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