INT178487

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Cnot4) nucleus (Cnot4) ligase activity (Cnot4)
cytoplasm (Cnot4)
Anatomy Link Frequency
muscle 1
platelet 1
Cnot4 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 17 100.00 Very High Very High Very High
alcohol 8 95.44 Very High Very High Very High
chemokine 3 68.28 Quite High
cocaine 17 5.00 Very Low Very Low Very Low
Morphine 13 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Eae 9 5.00 Very Low Very Low Very Low
addiction 9 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
narcan 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 105 97.04 Very High Very High Very High
Glioma 3 96.88 Very High Very High Very High
Colon Cancer 6 90.80 High High
Anxiety Disorder 29 89.92 High High
Frailty 73 86.80 High High
Metastasis 14 86.52 High High
Cancer 171 84.68 Quite High
Squamous Cell Carcinoma 3 81.60 Quite High
Increased Venous Pressure Under Development 1 79.32 Quite High
Melanoma 17 74.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This factor is regulated by a QTL on chromosome 9 which contains the Scn4b, an expression correlate of both ethanol withdrawal and Factor 4.


Gene_expression (expression) of Factor 4 associated with withdrawal
1) Confidence 0.05 Published 2010 Journal Genes, Brain, and Behavior Section Body Doc Link PMC2855868 Disease Relevance 0.58 Pain Relevance 0.14
Using retroviral and adenoviral vectors to express a secretable form of platelet factor 4, they demonstrated growth inhibition of and hypovascularity in intracerebral gliomas in the PF4-transduced group.
Gene_expression (express) of factor 4 in platelet associated with glioma
2) Confidence 0.01 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.00 Pain Relevance 0.06
It has been hypothesized that creatine increases the expression of myogenic transcription factors such as myogenin and myogenic regulatory factor-4, which increases muscle mass and strength.119 Creatine supplementation increases muscle phosphocreatine levels leading to a decrease in muscle relaxation time.120,121 This may increase the ability to perform high-intensity exercise as well as enhance muscle protein synthesis, lean skeletal muscle mass, and strength during periods of high intensity training.
Gene_expression (expression) of factor-4 in muscle
3) Confidence 0.01 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2938029 Disease Relevance 0.28 Pain Relevance 0

General Comments

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