INT17849

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Context Info
Confidence 0.38
First Reported 1991
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.20

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small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 92.44 High High
anticonvulsant 1 74.96 Quite High
Dismenorea 1 47.28 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 1 84.36 Quite High
INFLAMMATION 2 75.00 Quite High
Reprotox - General 1 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of the structural and the energetic data provides evidence supporting that network of hydrogen bonds between Tyr355, Glu524, Arg120 and Arg513 might be involved in mediating the binding of the time-dependent inhibitors of PGHS-2.
Negative_regulation (inhibitors) of PGHS-2 Spec (might) Binding (binding) of
1) Confidence 0.38 Published 2002 Journal J. Mol. Graph. Model. Section Abstract Doc Link 11858641 Disease Relevance 0.07 Pain Relevance 0.17
The drugs seemed to interfere with the action of the PG endoperoxide synthase (or PG cyclooxygenase) enzyme resulting in decreased formation of PGG2 and PGH2.
Negative_regulation (decreased) of PGG2 Binding (formation) of
2) Confidence 0.00 Published 1991 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 1946560 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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