INT178491

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.62
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col18a1) extracellular region (Col18a1) cell adhesion (Col18a1)
proteinaceous extracellular matrix (Col18a1) structural molecule activity (Col18a1) extracellular matrix organization (Col18a1)
Anatomy Link Frequency
platelet 1
Col18a1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 16 89.40 High High
cytokine 10 52.08 Quite High
chemokine 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 340 99.64 Very High Very High Very High
Apoptosis 30 93.44 High High
Adhesions 8 87.68 High High
Death 4 66.60 Quite High
Leukemia 6 45.76 Quite Low
Toxicity 12 43.68 Quite Low
Recurrence 2 39.52 Quite Low
Colon Cancer 12 28.88 Quite Low
Malignant Neoplastic Disease 6 13.36 Low Low
Hematologic Neoplasms 4 11.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the combination of SU5416, VEGFR2 tyrosine kinase inhibitor and low-dose endostatin reduced tumor growth more efficiently than monotherapy alone [169].
Negative_regulation (inhibitor) of endostatin associated with cancer
1) Confidence 0.10 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.18 Pain Relevance 0
The more widely studied antiangiogenic agents include naturally occurring angiogenesis inhibitors (angiostatin, endostatin, thrombospondins, platelet factor-4, etc.); inhibitors of EC growth (TNP-470, thalidomide, interleukin-12 [IL-12] etc), inhibitors of proangiogenic molecules (antibodies, antisense and soluble receptors for FGF, VEGF); agents that interfere with basement membranes and extracellular matrix (tissue inhibitors of matrix metalloproteinases [TIMPs]); antibodies to adhesion molecules (?
Negative_regulation (inhibitors) of endostatin in platelet associated with metalloproteinase and adhesions
2) Confidence 0.05 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.45 Pain Relevance 0.07

General Comments

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