INT178494

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 9.77
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Angpt1) signal transduction (Angpt1) extracellular space (Angpt1)
extracellular region (Angpt1) plasma membrane (Angpt1)
Anatomy Link Frequency
lung 2
corneas 2
vasculature 1
colon 1
fibroblasts 1
Angpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 104 99.84 Very High Very High Very High
cytokine 83 99.60 Very High Very High Very High
Arthritis 10 94.36 High High
Somatostatin 2 91.84 High High
fibrosis 30 88.96 High High
interstitial cystitis 6 86.48 High High
Inflammation 69 85.84 High High
metalloproteinase 81 75.20 Quite High
chemokine 22 63.72 Quite High
antagonist 4 44.96 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 25 100.00 Very High Very High Very High
Rheumatoid Arthritis 104 99.84 Very High Very High Very High
Lung Injury 3 99.48 Very High Very High Very High
Cancer 604 99.44 Very High Very High Very High
Hypertension 4 98.64 Very High Very High Very High
Apoptosis 107 97.84 Very High Very High Very High
Vasculitis 5 97.52 Very High Very High Very High
Pressure And Volume Under Development 3 96.84 Very High Very High Very High
Injury 55 96.44 Very High Very High Very High
Glioma 9 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the marked reduction in mammary vasculature in Cox-2 null mammary tissues, the expression of several angiogenesis-associated genes was decreased (Figure 5b), including VEGF (which encodes vascular endothelial growth factor), Ang1 and Ang2 (which encode Tie-2 ligands), and Flk-1 and Flt-1 (which encode vascular endothelial growth factor receptors).
Gene_expression (expression) of Ang1 in vasculature
1) Confidence 0.37 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.56 Pain Relevance 0
The expression patterns of Ang-1 and Ang-2 in the tumor and tumor vessel microenvironment are complex and the precise role that each plays in tumor angiogenesis is still being avidly studied and debated [76].
Gene_expression (expression) of Ang-1 associated with cancer
2) Confidence 0.27 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.73 Pain Relevance 0.03
Expression of antisense RNA to Ang1 could reduce tumor volume, decrease MVD and increase apoptosis in nude mice [120].
Gene_expression (Expression) of Ang1 associated with cancer and apoptosis
3) Confidence 0.24 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.92 Pain Relevance 0
Recently, Stoeltzing et al liposomally transfected human colon cancer cells with an Ang-1 construct.
Gene_expression (transfected) of Ang-1 in colon associated with colon cancer
4) Confidence 0.24 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.91 Pain Relevance 0.03
Increased expression of Ang-1 was noted in mice treated with the transfected MSCs and persisted for 14 days until sacrifice [45].
Gene_expression (expression) of Ang-1
5) Confidence 0.21 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3022195 Disease Relevance 1.34 Pain Relevance 0.22
Another group proceeded to infect MSCs with angiopoietin-1 (Ang-1), an important mediator in the pathologic changes that occur in the lung in response to injury [45].
Gene_expression (infect) of Ang-1 in lung associated with injury
6) Confidence 0.18 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3022195 Disease Relevance 1.25 Pain Relevance 0.10
Another group proceeded to infect MSCs with angiopoietin-1 (Ang-1), an important mediator in the pathologic changes that occur in the lung in response to injury [45].
Gene_expression (infect) of angiopoietin-1 in lung associated with injury
7) Confidence 0.18 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3022195 Disease Relevance 1.25 Pain Relevance 0.09
Expression of angiopoietin-1 and angiopoietin-2 in RASFs is directly linked to their respective endothelium-specific tyrosine kinase receptors Tie-1 and Tie-2 [55].
Gene_expression (Expression) of angiopoietin-1 in endothelium
8) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.71 Pain Relevance 0.33
It has also been reported that Shh upregulates the expressions of VEGF and angiopoietin-1,-2 in cultured human lung fibroblasts [27].
Gene_expression (expressions) of angiopoietin-1 in fibroblasts
9) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.08 Pain Relevance 0
This angiogenesis-inducing effect of cytokines could be shown for angiopoietin-1, which is present in RA synovium and is upregulated in RASFs by TNF-?
Gene_expression (present) of angiopoietin-1 in synovium associated with rheumatoid arthritis and cytokine
10) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.62 Pain Relevance 0.34
As previous studies have shown, overexpression of VEGF, bFGF, PDGF, nitric oxide synthases, angiopoietin, and angiopoietin 2 were detected in alkali-burned corneas as early as 3 days [1].
Gene_expression (overexpression) of angiopoietin in corneas
11) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.70 Pain Relevance 0.07
As previous studies have shown, overexpression of VEGF, bFGF, PDGF, nitric oxide synthases, angiopoietin, and angiopoietin 2 were detected in alkali-burned corneas as early as 3 days [1].
Gene_expression (overexpression) of angiopoietin in corneas
12) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.70 Pain Relevance 0.07

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