INT178513

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (COL4A3) extracellular region (COL4A3) cell adhesion (COL4A3)
structural molecule activity (COL4A3)
COL4A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 8 75.44 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Squamous Cell Carcinoma 3 89.84 High High
Adhesions 4 88.40 High High
Disease 37 86.88 High High
Alport Syndrome 10 86.20 High High
Renal Failure 3 71.80 Quite High
Cancer 173 71.20 Quite High
Metastasis 14 64.76 Quite High
Melanoma 17 63.24 Quite High
Renal Disease 9 55.48 Quite High
Inborn Genetic Diseases 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
3 chain play a significant role in promoting angiogenesis, although the lack of it can also promote angiogenesis, given that the angiogenesis inhibitor tumstatin binds through this receptor [41].
tumstatin Binding (binds) of
1) Confidence 0.35 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.50 Pain Relevance 0.04
This study proved that the construct could produce a functional protein capable of trimerizing with COL4A3 and COL4A4 (Heikkilä et al. 2001).
COL4A3 Binding (trimerizing) of
2) Confidence 0.32 Published 2007 Journal Mamm Genome Section Body Doc Link PMC1998873 Disease Relevance 0.30 Pain Relevance 0
Figure 4 shows an example of a coexpression plot based on the number of sequence reads for a murine pSNP recently shown to affect the binding of miR-133a to a collagen precursor (Col4a3) (40).
Col4a3 Binding (binding) of
3) Confidence 0.24 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0 Pain Relevance 0

General Comments

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