INT178534

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SRD5A1) small molecule metabolic process (SRD5A1) endoplasmic reticulum (SRD5A1)
cytoplasm (SRD5A1)
SRD5A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 24 50.00 Quite Low
corticosteroid 3 31.60 Quite Low
Calcium channel 1 24.48 Low Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 3 98.02 Very High Very High Very High
Breast Cancer 23 97.96 Very High Very High Very High
Alopecia 10 97.38 Very High Very High Very High
Cancer 68 93.56 High High
Carcinoma 8 85.60 High High
Disease 6 84.00 Quite High
Adenocarcinoma 1 65.08 Quite High
Hirsutism 1 54.52 Quite High
Depression 35 50.00 Quite Low
Malignant Neoplastic Disease 1 48.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results provide the first evidence that expression levels of SRD5A1/2 are elevated whereas those of AKR1-3 are markedly decreased in breast carcinoma.
Positive_regulation (elevated) of SRD5A1 associated with breast cancer
1) Confidence 0.44 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.65 Pain Relevance 0
Both androgenetic alopecia and benign prostate hyperplasia are androgen dependent disorders and associated with in situ high levels of intracellular DHT and increased 5alpha-reductase activity.
Positive_regulation (increased) of 5alpha-reductase associated with benign prostatic hypertrophy and alopecia
2) Confidence 0.13 Published 2006 Journal BMC Clin Pharmacol Section Body Doc Link PMC1622749 Disease Relevance 0.58 Pain Relevance 0

General Comments

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