INT178572

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.51
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13) extracellular space (IL13) extracellular region (IL13)
cell-cell signaling (IL13) cytoplasm (IL13)
Anatomy Link Frequency
blood 4
T cells 4
lung 2
IL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 378 99.00 Very High Very High Very High
cytokine 481 97.24 Very High Very High Very High
antagonist 122 93.68 High High
rheumatoid arthritis 35 83.04 Quite High
aspirin 3 81.60 Quite High
Catecholamine 32 71.28 Quite High
agonist 60 67.36 Quite High
Arthritis 41 41.20 Quite Low
dexamethasone 11 25.60 Quite Low
withdrawal 6 25.56 Quite Low
Disease Link Frequency Relevance Heat
Asthma 972 99.40 Very High Very High Very High
INFLAMMATION 400 99.00 Very High Very High Very High
Cancer 18 98.84 Very High Very High Very High
Rhinitis 57 98.48 Very High Very High Very High
Conjunctiva Disease 3 96.80 Very High Very High Very High
Disease 147 96.24 Very High Very High Very High
Recurrence 6 92.64 High High
Eosinophilia 84 90.48 High High
Apoptosis 28 88.96 High High
Targeted Disruption 61 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decreased) of Gene_expression (levels) of IL-13 in blood
1) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.79 Pain Relevance 0.15
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decrease) of Gene_expression (levels) of IL-13 in blood
2) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.81 Pain Relevance 0.15
When rolipram, a phosphodiesterase 4 inhibitor, is added to the fluticasone-salmeterol combination, this triple combination inhibits IL-13 production by PBMCs from asthmatic patients [19].
Negative_regulation (inhibits) of Gene_expression (production) of IL-13 associated with asthma
3) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.64 Pain Relevance 0.08
and decreased IL-13 production [159].
Negative_regulation (decreased) of Gene_expression (production) of IL-13
4) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.02 Pain Relevance 0.08
It was interesting to see that propranolol caused a reduction of production of IL-13 to an amount that was much lower than that treated with IL-1?
Negative_regulation (reduction) of Gene_expression (production) of IL-13
5) Confidence 0.10 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.28 Pain Relevance 0.39
synergized with IL-4 in elevating IL-9 production, but inhibited IL-4 mediated IL-5, IL-10, and IL-13 production.


Negative_regulation (inhibited) of Gene_expression (production) of IL-13
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.11
Propranolol at 1 × 10-4 M also significantly reduced the enhancing effect of epinephrine on IL-8 production (p < 0.05, Fig. 3B), and at 1 × 10-4 and 1 × 10-5 M significantly reduced the enhancing effect of epinephrine on IL-13 production (p < 0.00005 and 0.0005, respectively, Fig. 3C).
Negative_regulation (reduced) of Gene_expression (production) of IL-13
7) Confidence 0.09 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.17
In contrast, high-doses of montelukast reduce IL-4, IL-5 and IL-13 levels in the lung and IL-4 and IL-5 expression in BAL [39].
Negative_regulation (reduce) of Gene_expression (levels) of IL-13 in lung
8) Confidence 0.07 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.80 Pain Relevance 0.42
In addition, they suppressed the production of TNF, IL-10 and IL-13 whenever the responder T cells produced detectable amounts of these cytokines (Fig. 5).
Negative_regulation (suppressed) of Gene_expression (production) of IL-13 in T cells associated with cytokine
9) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464877 Disease Relevance 0.16 Pain Relevance 0.34
In murine splenic T cells, CD3-induced and CD3/CD28-induced IL-4 expression as well as CD30-induced IL-13 expression were also partly abrogated by SB203580 [44,46,67].
Negative_regulation (abrogated) of Gene_expression (expression) of IL-13 in T cells
10) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.06

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