INT178584

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CNTN2) plasma membrane (CNTN2)
CNTN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 97.86 Very High Very High Very High
Arthritis 13 65.92 Quite High
rheumatoid arthritis 17 60.64 Quite High
Inflammation 23 53.04 Quite High
Osteoarthritis 45 51.88 Quite High
iatrogenic 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Sicca syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 7 90.80 High High
Leukemia 19 90.44 High High
Cancer 23 80.92 Quite High
Hypercalcemia 1 78.96 Quite High
Malignant Neoplastic Disease 3 76.88 Quite High
Htlv Types I And Ii 14 75.76 Quite High
Infection 42 74.28 Quite High
Disease 23 68.84 Quite High
Arthritis 17 65.92 Quite High
Rheumatoid Arthritis 17 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Tax expression was not correlated with cytokine concentration in SF, probably owing to the time discrepancy between SF aspiration and tissue preparation, Tax expression in synoviocytes might be responsible, at least in part, for the increased concentrations of PTHrP, sIL-2R and IL-6 in SF of carrier patients.
Spec (might) Regulation (responsible) of Gene_expression (expression) of Tax associated with cytokine
1) Confidence 0.21 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.67 Pain Relevance 0.24
In cell culture, transfection of provirus 395 yields reduced levels of Tax activity (~ 10 % of wild-type) although the amount of major capsid protein p24 expressed inside the cells and in the supernatant remains unaffected.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expressed) of Tax
2) Confidence 0.16 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.72 Pain Relevance 0

General Comments

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