INT178590

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Context Info
Confidence 0.24
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.91
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CNTN2) plasma membrane (CNTN2)
Anatomy Link Frequency
epithelial cells 1
CNTN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 166 99.08 Very High Very High Very High
Arthritis 13 87.32 High High
Osteoarthritis 45 73.28 Quite High
Inflammation 31 70.84 Quite High
cytokine 26 68.24 Quite High
rheumatoid arthritis 17 53.92 Quite High
Neuropathic pain 4 53.40 Quite High
medulla 1 38.68 Quite Low
Spinal cord 1 37.96 Quite Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Isaacs Syndrome 50 98.16 Very High Very High Very High
Infection 115 94.88 High High
Epilepsy 35 90.72 High High
Disease 66 90.24 High High
Demyelinating Disease 5 89.08 High High
Arthritis 17 87.32 High High
Cancer 85 84.68 Quite High
Thymoma 14 80.04 Quite High
Leukemia 41 79.04 Quite High
Syndrome 89 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used the LAESI technique to identify metabolic changes in HTLV1 and Tax1 transformed T lymphocytes and in HTLV3 and Tax3 transfected kidney epithelial cells.
Regulation (changes) of Tax1 in epithelial cells
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0
The 21 bp enhancer is also a target of the Tax protein, a viral transcriptional activator which increases the binding of CREB to DNA [86].
Regulation (target) of Tax
2) Confidence 0.21 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0 Pain Relevance 0
In vitro, the tax/rex message which is not itself regulated by Rex [101], is present in the cytoplasm during an early phase preceding the accumulation of the other mRNA coding for the structural proteins [179].
Neg (not) Regulation (regulated) of tax
3) Confidence 0.16 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.19 Pain Relevance 0
subunit and IL-6 are cellular target genes of the Tax protein [27-29].
Regulation (target) of Tax
4) Confidence 0.13 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.84 Pain Relevance 0.33
in response to Tax peptides.
Regulation (response) of Tax
5) Confidence 0.12 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2698465 Disease Relevance 0.41 Pain Relevance 0
The targets for sera with lower VGKC antibodies should now be re-explored, but from our initial findings (unpublished observations) we anticipate that Kv1s, Caspr2 and contactin-2 will individually, or in combinations, prove to be targets in many patients with VGKC-antibody positive neuromyotonia, and also may be positive in some that are currently negative for VGKC-antibodies.
Regulation (targets) of contactin-2 associated with isaacs syndrome and potassium channel
6) Confidence 0.05 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.19 Pain Relevance 0.32
A patent has been filed by the University of Oxford claiming Caspr2, Lgi1 and Contactin-2 as targets for autoantibodies.


Regulation (targets) of Contactin-2
7) Confidence 0.05 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.29 Pain Relevance 0.03

General Comments

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