INT178604

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 13
Total Number 22
Disease Relevance 20.29
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TPX2) mitosis (TPX2) nucleolus (TPX2)
nucleus (TPX2) cell cycle (TPX2) cell division (TPX2)
Anatomy Link Frequency
synovium 1
TPX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1305 100.00 Very High Very High Very High
Osteoarthritis 252 100.00 Very High Very High Very High
cytokine 73 97.76 Very High Very High Very High
Arthritis 18 97.12 Very High Very High Very High
antagonist 75 83.16 Quite High
Inflammation 74 5.00 Very Low Very Low Very Low
COX-2 inhibitor 45 5.00 Very Low Very Low Very Low
cINOD 18 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Analgesic 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1305 100.00 Very High Very High Very High
Adhesions 675 100.00 Very High Very High Very High
Apoptosis 451 100.00 Very High Very High Very High
Osteoarthritis 261 100.00 Very High Very High Very High
Death 143 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 327 99.84 Very High Very High Very High
Seronegative Spondarthritis 9 97.12 Very High Very High Very High
Disease 160 95.08 Very High Very High Very High
Cancer 147 94.16 High High
Colon Cancer 20 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
shRNA expression vectors for 7 genes (IGF2R, SREBF2, AKAP11, TFAP2A, LHX3, TPX2 and ING1) were prepared as described [15].
Gene_expression (expression) of TPX2
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958829 Disease Relevance 0.17 Pain Relevance 0
Endogenously produced PGE2 associated with diosgenin-induced human RA FLS apoptosis
Gene_expression (apoptosis) of RA FLS associated with rheumatoid arthritis and apoptosis
2) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.81 Pain Relevance 0.12
In our study, caspase-3 activity and DNA fragmentation were analyzed in human RA FLS treated or not with 40 ?
Spec (analyzed) Gene_expression (analyzed) of RA FLS associated with rheumatoid arthritis
3) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.62 Pain Relevance 0.19
In our study, caspase-3 activity and DNA fragmentation were analyzed in human RA FLS treated or not with 40 ?
Neg (not) Gene_expression (treated) of RA FLS associated with rheumatoid arthritis
4) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.66 Pain Relevance 0.21
Moreover, human RA FLS were stained with DAPI (0.5 ?
Gene_expression (stained) of RA FLS associated with rheumatoid arthritis
5) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.32 Pain Relevance 0.16
Up-regulation of COX-2 expression and activity in diosgenin-induced RA FLS death
Gene_expression (death) of RA FLS associated with rheumatoid arthritis and death
6) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.83 Pain Relevance 0.11
Direct observation with phase-contrast microscopy demonstrated that human RA FLS treated with 40 ?
Gene_expression (treated) of RA FLS associated with rheumatoid arthritis
7) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.42 Pain Relevance 0.18
Human RA FLS were grown for 48 hours before treatment with 40?
Gene_expression (grown) of RA FLS associated with rheumatoid arthritis
8) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.35 Pain Relevance 0.18
In our study, caspase-3 activity and DNA fragmentation were analyzed in human RA FLS treated or not with 40 ?
Neg (not) Gene_expression (not) of RA FLS associated with rheumatoid arthritis
9) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.72 Pain Relevance 0.21
Human RA FLS are major producers of IL-6 and IL-8 in synovium and these proinflammatory cytokines participate in the pathogenesis of RA.
Gene_expression (producers) of RA FLS in synovium associated with rheumatoid arthritis and cytokine
10) Confidence 0.10 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.58 Pain Relevance 0.30
However, reports from the VCT counsellors providing services in this ward and FLs talking about "others" suggests that the belief in spiritual cures for HIV may lead some ART users to discontinue treatment.
Gene_expression (talking) of FLs associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.05 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2916904 Disease Relevance 0.56 Pain Relevance 0
In contexts where ambivalent attitudes towards the new drugs prevail, enhancing FLs understanding of ART's strengths and pitfalls is an essential step to gain their support and engage them as active partners in scale-up programs.
Gene_expression (understanding) of FLs
12) Confidence 0.05 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2916904 Disease Relevance 0.48 Pain Relevance 0
As reflected in the figure, the FLs explanations of AIDS symptoms are compatible with both the traditional (malevolent spirits) and biomedical (viral) explanations of the disease.
Gene_expression (explanations) of FLs associated with acquired immune deficiency syndrome or hiv infection and disease
13) Confidence 0.05 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2916904 Disease Relevance 0.57 Pain Relevance 0
The specific and early effect of adrenomedullin on RA-FLS adhesion to ECM proteins suggested activation of latent adhesion molecules.
Gene_expression (adhesion) of FLS associated with rheumatoid arthritis and adhesions
14) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.28 Pain Relevance 0.23
We evaluated RA-FLS adhesion after exposure to various adrenomedullin concentrations.
Gene_expression (adhesion) of FLS associated with rheumatoid arthritis and adhesions
15) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.06 Pain Relevance 0.19
Given previous evidence that RA-FLSs expressed more adrenomedullin and adrenomedullin receptors (CLR/RAMP-2 and CLR/RAMP-3) than did OA-FLS [10], we compared the effect of adrenomedullin on RA-FLSs and OA-FLSs.
Gene_expression (expressed) of FLS associated with rheumatoid arthritis and osteoarthritis
16) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.77 Pain Relevance 0.54
For these reasons, we selected fibronectin, vitronectin, and Coll.I for our study of RA-FLS adhesion.
Gene_expression (adhesion) of FLS associated with rheumatoid arthritis and adhesions
17) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.61 Pain Relevance 0.67
The 10-7 M adrenomedullin significantly enhanced RA-FLS adhesion to all three ECM proteins (Figure 1a), with a 2.39-, 2.25-, and 1.65-fold increase for vitronectin, fibronectin, and Coll.I, respectively (all with P < 0.0001).
Gene_expression (adhesion) of FLS associated with rheumatoid arthritis and adhesions
18) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.84 Pain Relevance 0.13
We found that adrenomedullin specifically increased RA-FLS adhesion to ECM proteins but had no effect on OA-FLS adhesion.
Gene_expression (adhesion) of FLS associated with rheumatoid arthritis, osteoarthritis and adhesions
19) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 2.32 Pain Relevance 0.93
We found that adrenomedullin specifically increased RA-FLS adhesion to ECM proteins but had no effect on OA-FLS adhesion.
Gene_expression (adhesion) of FLS associated with rheumatoid arthritis, osteoarthritis and adhesions
20) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 2.34 Pain Relevance 0.92

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