INT178606

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 8.73
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TPX2) mitosis (TPX2) nucleolus (TPX2)
nucleus (TPX2) cell cycle (TPX2) cell division (TPX2)
TPX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 440 100.00 Very High Very High Very High
Osteoarthritis 110 100.00 Very High Very High Very High
Arthritis 8 97.64 Very High Very High Very High
antagonist 33 82.16 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
COX-2 inhibitor 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 440 100.00 Very High Very High Very High
Adhesions 300 100.00 Very High Very High Very High
Osteoarthritis 112 100.00 Very High Very High Very High
Apoptosis 102 100.00 Very High Very High Very High
Death 32 100.00 Very High Very High Very High
Seronegative Spondarthritis 4 97.64 Very High Very High Very High
Cancer 28 94.16 High High
Colon Cancer 4 91.92 High High
Disease 51 84.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 108 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenously produced PGE2 associated with diosgenin-induced human RA FLS apoptosis
Positive_regulation (induced) of Gene_expression (apoptosis) of RA FLS associated with rheumatoid arthritis and apoptosis
1) Confidence 0.08 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.81 Pain Relevance 0.12
Up-regulation of COX-2 expression and activity in diosgenin-induced RA FLS death
Positive_regulation (induced) of Gene_expression (death) of RA FLS associated with rheumatoid arthritis and death
2) Confidence 0.08 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464911 Disease Relevance 0.88 Pain Relevance 0.14
In contexts where ambivalent attitudes towards the new drugs prevail, enhancing FLs understanding of ART's strengths and pitfalls is an essential step to gain their support and engage them as active partners in scale-up programs.
Positive_regulation (enhancing) of Gene_expression (understanding) of FLs
3) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2916904 Disease Relevance 0.49 Pain Relevance 0
The 10-7 M adrenomedullin significantly enhanced RA-FLS adhesion to all three ECM proteins (Figure 1a), with a 2.39-, 2.25-, and 1.65-fold increase for vitronectin, fibronectin, and Coll.I, respectively (all with P < 0.0001).
Positive_regulation (enhanced) of Gene_expression (adhesion) of FLS associated with rheumatoid arthritis and adhesions
4) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.84 Pain Relevance 0.13
We found that adrenomedullin specifically increased RA-FLS adhesion to ECM proteins but had no effect on OA-FLS adhesion.
Positive_regulation (increased) of Gene_expression (adhesion) of FLS associated with rheumatoid arthritis, osteoarthritis and adhesions
5) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 2.46 Pain Relevance 0.97
For these reasons, we selected fibronectin, vitronectin, and Coll.I for our study of RA-FLS adhesion.
Positive_regulation (selected) of Gene_expression (adhesion) of FLS associated with rheumatoid arthritis and adhesions
6) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.63 Pain Relevance 0.67
For these reasons, we selected fibronectin, vitronectin, and Coll.I for our study of RA-FLS adhesion.
Positive_regulation (selected) of Gene_expression (selected) of FLS associated with rheumatoid arthritis and adhesions
7) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.62 Pain Relevance 0.67

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