INT17861

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Context Info
Confidence 0.50
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.05
Pain Relevance 0.21

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oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Anatomy Link Frequency
liver 2
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 1 94.88 High High
Bile 1 79.40 Quite High
anesthesia 1 76.72 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 53.96 Quite High
Obesity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2.
Positive_regulation (induction) of Localization (excretion) of CYP1A2
1) Confidence 0.50 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.12
Collectively, BF has inducing potential of liver CYP1A2 and CYP2E1 and may influence the corresponding pharmacokinetics of other drugs.
Positive_regulation (inducing) of Localization (potential) of CYP1A2 in liver
2) Confidence 0.47 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.05 Pain Relevance 0.09

General Comments

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