INT178615

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 6.93
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
chest 1
kidney 1
SOD2 (Homo sapiens)
SOD2 - A9V (1)
Pain Link Frequency Relevance Heat
cINOD 350 100.00 Very High Very High Very High
cytokine 13 97.48 Very High Very High Very High
Inflammation 19 97.08 Very High Very High Very High
alcohol 91 91.84 High High
metalloproteinase 10 78.28 Quite High
aspirin 10 5.00 Very Low Very Low Very Low
Paracetamol 10 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 440 100.00 Very High Very High Very High
Diabetes Mellitus 180 99.76 Very High Very High Very High
Nicotine Addiction 140 99.24 Very High Very High Very High
Cancer 80 98.92 Very High Very High Very High
Diabetes Complications 3 98.56 Very High Very High Very High
INFLAMMATION 48 97.08 Very High Very High Very High
Stress 24 94.28 High High
Vascular Disease 9 93.44 High High
Ureteral Obstruction 25 89.28 High High
Endometriosis (extended) 30 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also identified a possible antagonistic interaction between NSAID use and the MnSOD genotype.
MnSOD Binding (interaction) of associated with cinod
1) Confidence 0.48 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.35 Pain Relevance 0.10
Mitrunen and colleagues [15] reported an elevated OR for the MnSOD genotype among smokers, while Egan and colleagues [16] reported a stronger association for the MnSOD genotype in never smokers than in ever smokers.
MnSOD Binding (association) of associated with nicotine addiction
2) Confidence 0.48 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.48 Pain Relevance 0.04
The ICRs suggested positive interaction on an additive scale for each of these exposures and the MnSOD Ala/Ala genotype.
MnSOD Spec (suggested) Binding (interaction) of
3) Confidence 0.37 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.43 Pain Relevance 0.04
P values for likelihood ratio tests were less than 0.10 only for the interaction of the MnSOD genotype and high-dose radiation to the chest (P = 0.009).
MnSOD Binding (interaction) of in chest
4) Confidence 0.37 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.32 Pain Relevance 0.17
Several epidemiologic studies have examined the association of the MnSOD Ala-9Val polymorphism and cancer.
MnSOD Spec (examined) Binding (association) of associated with cancer
5) Confidence 0.37 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.60 Pain Relevance 0
Previous studies of the MnSOD genotype and breast cancer did not investigate interactions with radiation exposure.
MnSOD Binding (interactions) of associated with breast cancer
6) Confidence 0.37 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.33 Pain Relevance 0.07
Finally, the MnSOD Ala-9Val polymorphism may interact with polymorphisms in other genes involved in modulating levels of oxidative damage that were not measured in our study.
MnSOD (A9V) Binding (interact) of
7) Confidence 0.36 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.06 Pain Relevance 0.09
The amino acid change occurs within the N-terminal mitochondrial targeting sequence, a 24-amino acid signal sequence that targets the MnSOD precursor protein for transport into the mitochondria.
MnSOD Binding (targets) of
8) Confidence 0.36 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.30 Pain Relevance 0.04
Genotyping for additional loci that could interact with MnSOD was not conducted for study participants.


MnSOD Binding (interact) of
9) Confidence 0.36 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.16 Pain Relevance 0.08
Interactions between NSAIDs and the MnSOD genotype suggest that both factors operate on a common biochemical pathway or series of pathways.
MnSOD Binding (Interactions) of associated with cinod
10) Confidence 0.36 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468618 Disease Relevance 0.55 Pain Relevance 0.88
This analysis indicated that SOD1 and SOD2 genotypes are significantly associated with macroangiopathy.
SOD2 Binding (associated) of
11) Confidence 0.35 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.95 Pain Relevance 0
The association of enzyme activity and polymorphisms in SOD1 and SOD2 with diabetes control and vascular complications of diabetes mellitus
SOD2 Binding (association) of associated with diabetes complications and diabetes mellitus
12) Confidence 0.35 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.84 Pain Relevance 0
Association of the SOD1, SOD2 and CAT polymorphism, BMI, age, duration of diabetes, sex, type of diabetes and SOD activity as independent variables with the presence of microangiopathy or macroangiopathy as dependent variables was performed using a logistic regression model.
SOD2 Binding (Association) of associated with diabetes mellitus
13) Confidence 0.35 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.82 Pain Relevance 0
MnSOD is a superoxide scavenger while Nox-2 is one of the key generators of superoxide in the kidney [7].
MnSOD Binding (scavenger) of in kidney
14) Confidence 0.05 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.72 Pain Relevance 0

General Comments

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