INT17862

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Context Info
Confidence 0.74
First Reported 1990
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.34
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Anatomy Link Frequency
hepatocyte 1
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dextromethorphan 5 99.56 Very High Very High Very High
Codeine 10 98.46 Very High Very High Very High
Morphine 1 98.20 Very High Very High Very High
Bile 1 78.96 Quite High
anesthesia 1 76.28 Quite High
cINOD 1 73.28 Quite High
Paracetamol 4 50.00 Quite Low
endometriosis 2 50.00 Quite Low
Dismenorea 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 4 98.56 Very High Very High Very High
Endometriosis (extended) 2 74.64 Quite High
INFLAMMATION 1 73.04 Quite High
Obesity 2 32.04 Quite Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2.
Localization (excretion) of CYP1A1
1) Confidence 0.74 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.12
Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.
Localization (presence) of cytochrome P-450IID1 associated with dextromethorphan, codeine and morphine
2) Confidence 0.60 Published 1990 Journal Clin. Pharmacol. Ther. Section Title Doc Link 2295216 Disease Relevance 0 Pain Relevance 1.15
RESULT(S): All affected family members had genotype CYP1A1 wt/m1 and GSTM1 null deletion.
Localization (deletion) of CYP1A1
3) Confidence 0.33 Published 2001 Journal Fertil. Steril. Section Body Doc Link 11730751 Disease Relevance 0.07 Pain Relevance 0
Increasing recognition that formation of a CoA conjugate increases chemical reactivity of xenobiotic carboxylic acids has led to an awareness that the relative activity, substrate specificity and intracellular location of the xenobiotic-CoA ligases may explain differences in toxicity. 5.
Localization (location) of xenobiotic-CoA associated with toxicity
4) Confidence 0.06 Published 1998 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 9784915 Disease Relevance 0.17 Pain Relevance 0.07
METHODS: We investigated the effect of incubation of rat hepatocytes and 3 hepatocyte cell lines with acetaminophen or N-acetyl-p-benzoquinoneimine on LDH release, glutathione status, mitochondrial function, CYP1A activity, albumin synthesis and DNA content.
Localization (release) of CYP1A in hepatocyte
5) Confidence 0.05 Published 1999 Journal J. Hepatol. Section Body Doc Link 10580581 Disease Relevance 0.09 Pain Relevance 0

General Comments

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