INT178629

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 36.96 Quite Low
addiction 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 39 98.64 Very High Very High Very High
Cancer 83 83.28 Quite High
Hyperglycemia 2 76.96 Quite High
Mucositis 1 57.08 Quite High
Diarrhoea 3 56.28 Quite High
Toxicity 2 46.96 Quite Low
Targeted Disruption 3 42.56 Quite Low
Hypertension 1 39.12 Quite Low
Headache 1 36.96 Quite Low
Peripheral Arterial Disease 1 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the setting of hormone receptor positive breast cancer, mTOR inhibition and the resulting increase in Akt signaling could result in ER phosphorylation on Ser167 and negate the effects of aromatase inhibition, thus limiting the therapeutic benefit of this combination.


Positive_regulation (result) of Phosphorylation (phosphorylation) of ER associated with breast cancer
1) Confidence 0.36 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.65 Pain Relevance 0
Because ERK1/2 phosphorylates (activates) ER-?
Positive_regulation (activates) of Phosphorylation (phosphorylates) of ER
2) Confidence 0.02 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.28 Pain Relevance 0

General Comments

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