INT178631

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 9.16
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
reticulum 2
plasma 1
arms 1
MCF-7 1
face 1
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 99 100.00 Very High Very High Very High
agonist 94 99.84 Very High Very High Very High
antagonist 23 97.20 Very High Very High Very High
Migraine 77 96.96 Very High Very High Very High
cocaine 294 96.44 Very High Very High Very High
Eae 3 93.68 High High
Kinase C 24 93.08 High High
Inflammation 121 90.16 High High
Calcium channel 30 88.20 High High
Central nervous system 55 85.72 High High
Disease Link Frequency Relevance Heat
Stress 98 100.00 Very High Very High Very High
Breast Cancer 379 99.70 Very High Very High Very High
Cancer 768 99.12 Very High Very High Very High
Headache 71 96.96 Very High Very High Very High
Colitis 69 95.96 Very High Very High Very High
Disease 211 95.48 Very High Very High Very High
Apoptosis 133 93.96 High High
Migraine With Aura 30 91.68 High High
Carcinoma 20 90.60 High High
INFLAMMATION 127 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[34] and with P27Kip1 as a mediator of cell-cycle arrest action of ER?
Phosphorylation (action) of ER
1) Confidence 0.75 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.47 Pain Relevance 0
In contrast, a preoperative trial by Polychronis and colleagues [21] comparing single-agent gefitinib to gefitinib combined with anastrozole for four to six weeks prior to surgery demonstrated that both treatment arms effectively reduced the size of breast tumors and levels of ER phosphorylation, with the combination treatment outperforming gefitinib alone in terms of reduction in tumor proliferation rate as measured by Ki67 [19].
Phosphorylation (phosphorylation) of ER in arms associated with cancer and breast cancer
2) Confidence 0.63 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.56 Pain Relevance 0
For example, both MAPK and Akt have been shown to directly phosphorylate ER, at Ser118 and Ser167, respectively [8,9].
Phosphorylation (phosphorylate) of ER
3) Confidence 0.63 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.35 Pain Relevance 0
In the setting of hormone receptor positive breast cancer, mTOR inhibition and the resulting increase in Akt signaling could result in ER phosphorylation on Ser167 and negate the effects of aromatase inhibition, thus limiting the therapeutic benefit of this combination.


Phosphorylation (phosphorylation) of ER associated with breast cancer
4) Confidence 0.63 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.65 Pain Relevance 0
These pathways activate downstream effectors, which phosphorylate ER?
Phosphorylation (phosphorylate) of ER
5) Confidence 0.63 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.26 Pain Relevance 0
The value of ER?
Phosphorylation (value) of ER
6) Confidence 0.57 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.15 Pain Relevance 0.11
The trial is ongoing and biomarker analyses are underway to assess whether EGFR, HER2 or ER phophorylation at Ser118 may predict for benefit from this combination.
Phosphorylation (phophorylation) of ER
7) Confidence 0.55 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.61 Pain Relevance 0
Nevertheless the same study does not confirm the positive association of the variants of ESR1 (oestrogen receptor ?
Phosphorylation (variants) of ESR1
8) Confidence 0.48 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 1.24 Pain Relevance 0.89
Data shown above indeed suggest that bisphosphonate-treated MCF-7 cells keep a functional form of ER, which should be able to promote the anti-proliferative action of ER antagonists.
Phosphorylation (form) of ER in MCF-7 associated with antagonist
9) Confidence 0.37 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0 Pain Relevance 0.05
-mediated compensatory inhibition in the face of ER?
Phosphorylation (face) of ER in face
10) Confidence 0.28 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.09 Pain Relevance 0.11
The results shown in Figure 9 indicated that the vapor phase is as efficient as whole CS in inducing ER stress and the phosphorylation of eIF2?.
Phosphorylation (phosphorylation) of ER associated with stress
11) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.30 Pain Relevance 0
and/or ER?
Phosphorylation (/) of ER
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0.10 Pain Relevance 0.03
The activation of the MAPK and AKT can phosphorylate downstream factors, such as CREB, which was phosphorylated by the ER?
Phosphorylation (phosphorylated) of ER
13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.55
Upon ER stress such as ER oxidation, the ER sensor protein PERK phosphorylates eIF2?
Phosphorylation (phosphorylates) of ER associated with stress
14) Confidence 0.08 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.53 Pain Relevance 0.43
Secondly, ICP34.5 takes part in blocking the stress response of endoplasmic reticulum (ER) via phosphorilation of ER resident kinase PERK [19].
Phosphorylation (phosphorilation) of ER in reticulum associated with stress
15) Confidence 0.05 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.39 Pain Relevance 0
Secondly, ICP34.5 takes part in blocking the stress response of endoplasmic reticulum (ER) via phosphorilation of ER resident kinase PERK [19].
Phosphorylation (phosphorilation) of ER in reticulum associated with stress
16) Confidence 0.05 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.39 Pain Relevance 0
Until recently, only one form of ER was known to exist.20,21 With the discovery of a new form of the receptor, the ER?
Phosphorylation (form) of ER
17) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899785 Disease Relevance 0.62 Pain Relevance 0.08
Because ERK1/2 phosphorylates (activates) ER-?
Phosphorylation (phosphorylates) of ER
18) Confidence 0.04 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.28 Pain Relevance 0
The C1 cassette contains four serines that are known phosphorylation sites and an ER retention signal.
Phosphorylation (phosphorylation) of ER
19) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.35 Pain Relevance 0.44
Phosphorylation of the serines blocks the ER retention signal and allows transport of the receptors to the plasma membrane [42-44].
Phosphorylation (Phosphorylation) of ER in plasma
20) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.36 Pain Relevance 0.38

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