INT178632

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 1.56
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
brain 6
mammary gland 4
uterus 4
uterine 2
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 188 99.90 Very High Very High Very High
antagonist 91 98.56 Very High Very High Very High
amygdala 144 95.04 Very High Very High Very High
addiction 16 94.00 High High
anesthesia 23 93.12 High High
agonist 104 85.76 High High
Pain 4 67.92 Quite High
Neurotransmitter 10 53.60 Quite High
withdrawal 4 51.96 Quite High
isoflurane 2 50.32 Quite High
Disease Link Frequency Relevance Heat
Cancer 189 95.68 Very High Very High Very High
Decapitation 10 94.80 High High
Breast Cancer 27 86.48 High High
Anxiety Disorder 4 74.08 Quite High
Body Weight 25 71.64 Quite High
Aids-related Complex 28 71.52 Quite High
Targeted Disruption 51 55.12 Quite High
Peripheral Arterial Disease 7 33.68 Quite Low
Functional Bowel Disorder 2 23.00 Low Low
Vomiting 2 21.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PR mRNA levels do not vary in the rat uterus during the estrous cycle, suggesting that the expression of PR is primarily regulated post-translationally and/or translationally [30].
Regulation (regulated) of Gene_expression (expression) of PR in uterus
1) Confidence 0.35 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.07 Pain Relevance 0
Dramatic changes in PR expression have been shown during the estrous cycle and in early pregnancy [8].
Regulation (changes) of Gene_expression (expression) of PR
2) Confidence 0.35 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.11 Pain Relevance 0
Therefore, we performed proliferation-specific analyses and determined expression of the progesterone receptor (PR), which is stimulated in the mammary gland after E2 exposure (Tekmal et al. 2005).
Spec (analyses) Regulation (proliferation) of Spec (determined) Gene_expression (expression) of PR in mammary gland
3) Confidence 0.25 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.23 Pain Relevance 0.12
Therefore, we performed proliferation-specific analyses and determined expression of the progesterone receptor (PR), which is stimulated in the mammary gland after E2 exposure (Tekmal et al. 2005).
Spec (analyses) Regulation (proliferation) of Spec (determined) Gene_expression (expression) of progesterone receptor in mammary gland
4) Confidence 0.25 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.23 Pain Relevance 0.09
These data suggest that DA can regulate PR expression within restricted regions of developing brain.
Regulation (regulate) of Gene_expression (expression) of PR in brain associated with dopamine
5) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.48
We have also recently reported that endogenous dopaminergic neurotransmission appears to play a role in regulating the normal expression of PR within the neonatal rat brain.
Regulation (regulating) of Gene_expression (expression) of PR in brain
6) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.63
Those investigators showed that the phosphatidylinositol 3-kinase (PI3-K)/Act pathway was involved in regulating the enhanced PR expression.
Regulation (regulating) of Gene_expression (expression) of PR
7) Confidence 0.22 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.28 Pain Relevance 0
Therefore, the effects of IGF-I on PR expression may differ depending on whether they are achieved through stimulating ER-?
Spec (whether) Regulation (through) of Gene_expression (expression) of PR
8) Confidence 0.22 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.19 Pain Relevance 0
is an essential regulator of the expression of PR [52], we conclude from these results that the IGF-I treatment caused increased activation of the MAPK cascade, resulting in increased activation of ER-?
Regulation (regulator) of Gene_expression (expression) of PR
9) Confidence 0.20 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.28 Pain Relevance 0
Additionally, previous studies indicate that treatment with this dose of another ER antagonist, tamoxifen, 2h prior to SKF 38393 treatment is sufficient to block the effects of dopaminergic activation of ER on PR expression and social play behavior [15].
Regulation (effects) of Gene_expression (expression) of PR associated with antagonist
10) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.09 Pain Relevance 0.30
Estradiol (E2) and progesterone (P) are well known regulators of progesterone receptor (PR) expression in the rat uterus.
Regulation (regulators) of Gene_expression (expression) of PR in uterus
11) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0
Thus, these results made Ohta et al. conclude that uterine PR expression is regulated by ovarian steroids during the estrous cycle and early pregnancy [8].
Regulation (regulated) of Gene_expression (expression) of PR in uterine
12) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0
These data are consistent with our previous findings indicating that ERs mediate DA action in the developing rat brain to alter PR expression only within restricted brain regions [15], [17].
Regulation (alter) of Gene_expression (expression) of PR in brain associated with dopamine
13) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.07 Pain Relevance 0.63
In contrast, ezlopitant treatment had no overall main effect the breakpoint during PR tests for the 10% ethanol group [F(4,13)?
Neg (no) Regulation (had) of Gene_expression (tests) of PR
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931709 Disease Relevance 0 Pain Relevance 0
Ezlopitant treatment had an overall main effect on the breakpoint during PR tests for the 5% sucrose group [F(3,13)?
Regulation (effect) of Gene_expression (tests) of PR
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931709 Disease Relevance 0 Pain Relevance 0

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