INT178637

Context Info Confidence 0.03 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.17 Pain Relevance 0

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1) protein complex (ESR1) cytoplasm (ESR1) extracellular space (Igf1)

Igf1 (Rattus norvegicus) ESR1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Cancer 114 95.36 Breast Cancer 18 48.04 Targeted Disruption 6 16.68 Body Weight 6 5.00 Spontaneous Abortion 2 5.00 Adenocarcinoma 2 5.00 Apoptosis 2 5.00 Fibroadenoma 2 5.00 Peripheral Arterial Disease 2 5.00 Carcinoma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The IGF-I stimulated increase in ER-?

IGF-I Positive_regulation (increase) of ER

1) Confidence 0.03 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.10 Pain Relevance 0

, but results from cell culture studies have shown that IGF-I can activate ER-?

IGF-I Positive_regulation (activate) of ER

2) Confidence 0.03 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.