INT17865

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 5 99.78 Very High Very High Very High
fluoxetine 4 98.00 Very High Very High Very High
Endep 2 85.44 High High
Desipramine 1 79.00 Quite High
sSRI 1 55.36 Quite High
anesthesia 1 52.16 Quite High
Bile 1 49.24 Quite Low
Disease Link Frequency Relevance Heat
Obesity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of CYP1A2 (RIA) by TBDD appeared to be a more sensitive response over the dose range studied.
Regulation (response) of Positive_regulation (Induction) of CYP1A2
1) Confidence 0.45 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.05
We conclude that the tested antidepressant drugs may affect the metabolism of caffeine not only in a direct way (binding to the enzyme), but also indirectly via inducing CYP1A2 (sertraline and mirtazapine) and CYP2C isoforms (fluoxetine, sertraline, mirtazapine) after prolonged administration.
Spec (may) Regulation (affect) of Positive_regulation (inducing) of CYP1A2 associated with antidepressant and fluoxetine
2) Confidence 0.45 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 18195463 Disease Relevance 0 Pain Relevance 0.69

General Comments

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