INT178663

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.24
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) cell adhesion (CXCR3) nucleus (TH1L)
plasma membrane (CXCR3) cytoplasm (CXCR3) signal transducer activity (CXCR3)
Anatomy Link Frequency
Th1 cells 1
lymphocytes 1
CXCR3 (Homo sapiens)
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 100.00 Very High Very High Very High
chemokine 66 99.46 Very High Very High Very High
Inflammatory response 6 98.60 Very High Very High Very High
Inflammation 24 98.42 Very High Very High Very High
cytokine 70 89.68 High High
Bioavailability 1 44.88 Quite Low
cINOD 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 28 98.60 Very High Very High Very High
Hypersensitivity 2 96.60 Very High Very High Very High
Mycobacterial Infection 4 95.08 Very High Very High Very High
Respiratory Syncytial Virus 100 88.72 High High
Disease 29 85.64 High High
Infection 76 84.56 Quite High
Viral Infection 5 82.08 Quite High
Targeted Disruption 2 77.36 Quite High
Influenza Virus Infection 2 75.44 Quite High
Viremia 2 60.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
were CXCR3 and CCR5 agonists, and therefore, likely to recruit Th1 lymphocytes, characteristic of an inflammatory response [19].
CXCR3 Spec (likely) Binding (likely) of Th1 in lymphocytes associated with inflammatory response and agonist
1) Confidence 0.04 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 1.05 Pain Relevance 0.44
CXCL10 is known for its activity to attract effector Th1 cells through interaction with its receptor CXCR3 at sites for the expression of Th1 immune responses [68], e.g., rejection of allografts or the inflammatory response upon mycobacterial infection [69],[70].
CXCR3 Binding (interaction) of Th1 in Th1 cells associated with mycobacterial infection and inflammatory response
2) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.25 Pain Relevance 0.08
High levels of anti-inflammatory IL-10 and the presence of high levels of chemokines IP-10 and MIG (ligands of CXCR3 associated with Th1-type reactions) [35], detected here would support this hypothesis.
CXCR3 Binding (associated) of Th1-type associated with chemokine and inflammation
3) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.94 Pain Relevance 0.49

General Comments

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