INT17867

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Context Info
Confidence 0.69
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 39
Total Number 39
Disease Relevance 2.58
Pain Relevance 7.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Anatomy Link Frequency
liver 8
adipose tissue 2
lung 2
kidney 2
plasma 1
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 12 100.00 Very High Very High Very High
Potency 2 100.00 Very High Very High Very High
algil 8 99.84 Very High Very High Very High
Duloxetine 84 99.62 Very High Very High Very High
agonist 4 99.50 Very High Very High Very High
carbamazepine 2 98.80 Very High Very High Very High
Paracetamol 42 98.64 Very High Very High Very High
antidepressant 9 97.62 Very High Very High Very High
sSRI 12 96.96 Very High Very High Very High
alcohol 4 93.16 High High
Disease Link Frequency Relevance Heat
Nicotine Addiction 14 99.52 Very High Very High Very High
Toxicity 3 97.80 Very High Very High Very High
Pressure Volume 2 Under Development 2 94.28 High High
Obesity 8 93.88 High High
Necrosis 1 80.52 Quite High
Acute-phase Reaction 1 75.96 Quite High
Poisoning 1 75.00 Quite High
Anxiety Disorder 4 73.56 Quite High
Hypersensitivity 1 71.60 Quite High
Headache 12 70.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of CYP1A2 (RIA) by TBDD appeared to be a more sensitive response over the dose range studied.
Positive_regulation (Induction) of CYP1A2
1) Confidence 0.69 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.05
Finally, comparison of hepatic CYP1A2 induction vs hepatic concentrations of TBDD 3 days following treatment with 10 vs 1 nmol/kg TBDD suggested that induction of CYP1A2 alone may not account for nonlinearities in dioxin disposition exemplified by dose-related increases in the ratio of dioxin concentrations in liver and adipose tissue.
Positive_regulation (induction) of CYP1A2 in adipose tissue associated with obesity
2) Confidence 0.69 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1949032 Disease Relevance 0.09 Pain Relevance 0
Finally, comparison of hepatic CYP1A2 induction vs hepatic concentrations of TBDD 3 days following treatment with 10 vs 1 nmol/kg TBDD suggested that induction of CYP1A2 alone may not account for nonlinearities in dioxin disposition exemplified by dose-related increases in the ratio of dioxin concentrations in liver and adipose tissue.
Positive_regulation (induction) of CYP1A2 in adipose tissue associated with obesity
3) Confidence 0.69 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1949032 Disease Relevance 0.09 Pain Relevance 0
We conclude that the tested antidepressant drugs may affect the metabolism of caffeine not only in a direct way (binding to the enzyme), but also indirectly via inducing CYP1A2 (sertraline and mirtazapine) and CYP2C isoforms (fluoxetine, sertraline, mirtazapine) after prolonged administration.
Positive_regulation (inducing) of CYP1A2 associated with antidepressant and fluoxetine
4) Confidence 0.69 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 18195463 Disease Relevance 0 Pain Relevance 0.66
The drugs paracetamol, antipyrine, imipramine and rifampicin resulted in diminished enzyme activity, indicating the absence of any induction of cytochrome P-448.
Positive_regulation (induction) of cytochrome P-448 associated with paracetamol
5) Confidence 0.69 Published 1984 Journal Xenobiotica Section Abstract Doc Link 6719936 Disease Relevance 0 Pain Relevance 0.10
In studies with the matched pairs of carcinogens and non-carcinogens, benzo[a]pyrene and benzo[e]pyrene, and 1,2,5,6-dibenzanthracene and anthracene, only the carcinogenic analogue resulted in induction of cytochrome P-448.
Positive_regulation (induction) of cytochrome P-448
6) Confidence 0.69 Published 1984 Journal Xenobiotica Section Abstract Doc Link 6719936 Disease Relevance 0 Pain Relevance 0.09
Omeprazole has been reported to increase cytochrome P450IA2 (CYP1A2) activity in vitro, but whether this effect also occurs in vivo is controversial.
Positive_regulation (increase) of CYP1A2
7) Confidence 0.68 Published 1994 Journal Ther Drug Monit Section Abstract Doc Link 8085279 Disease Relevance 0 Pain Relevance 0.07
The changes in the pharmacokinetics of acetaminophen resulting from the administration of In-Chen-How are related to an increase in metabolic activity of CYP1A2 and CYP2E1.
Positive_regulation (increase) of CYP1A2 associated with paracetamol
8) Confidence 0.67 Published 2007 Journal Yao Xue Xue Bao Section Abstract Doc Link 17520838 Disease Relevance 0 Pain Relevance 0.44
The levels of CYP1A2 and CYP2E1 in hepatic microsomal protein from pretreated group were increased as compared to that from the control group.
Positive_regulation (increased) of CYP1A2
9) Confidence 0.67 Published 2007 Journal Yao Xue Xue Bao Section Abstract Doc Link 17520838 Disease Relevance 0 Pain Relevance 0.48
The result indicated that BF significantly increased the activity and protein levels of CYP1A2 and CYP2E1, while the mRNA levels were elevated to a certain extent.
Positive_regulation (increased) of CYP1A2
10) Confidence 0.66 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.07 Pain Relevance 0.08
Induction of cytochrome P-448, as specifically measured by ethoxyresorufin O-deethylase activity, occurs in rat liver, kidney and lung after administration of the carcinogens, 3-methylcholanthrene, Aroclor 1254, 2-anthramine, safrole, 7,12-dimethylbenz[a]anthracene, MNNG and 2-acetamidofluorene.
Positive_regulation (Induction) of cytochrome P-448 in lung
11) Confidence 0.60 Published 1984 Journal Xenobiotica Section Abstract Doc Link 6719936 Disease Relevance 0 Pain Relevance 0.07
With alpha- and beta-naphthylamine, both resulted in marked induction of cytochrome P-448 in liver, kidney and lung, indicating that both isomers might be carcinogenic.
Positive_regulation (induction) of cytochrome P-448 in liver
12) Confidence 0.60 Published 1984 Journal Xenobiotica Section Abstract Doc Link 6719936 Disease Relevance 0 Pain Relevance 0.08
Duloxetine has no ability to induce CYP1A2, but is known to have mild inhibitory effects on the enzyme in vitro.
Neg (no) Positive_regulation (induce) of CYP1A2 associated with duloxetine
13) Confidence 0.58 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 0 Pain Relevance 0.57
In a second set of studies, the dose-response profiles for induction of cytochromes CYP1A1 and CYP1A2 by TBDD were characterized.
Positive_regulation (induction) of CYP1A2
14) Confidence 0.50 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.09
This study aso demonstrated that fluvoxamine may be a mechanism-based inactivator of CYP1A2.
Positive_regulation (inactivator) of CYP1A2
15) Confidence 0.50 Published 2003 Journal Chem. Biol. Interact. Section Abstract Doc Link 14642738 Disease Relevance 0 Pain Relevance 0
Before the toxic dose pretreated rats compared to control rats had higher activity of glutathione-S-transferase (liver) and alanine aminotransferase (serum), higher hepatic mRNA level of glutathione-S-transferase and gamma-glutamylcysteine synthetase heavy and light chain subunits, and lower hepatic concentration of glutathione, cysteine and mRNA of CYP1A2 than control rats.
Positive_regulation (concentration) of CYP1A2 in liver
16) Confidence 0.47 Published 2001 Journal Pharmacol. Toxicol. Section Abstract Doc Link 11245408 Disease Relevance 0.29 Pain Relevance 0.43
Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2.
Positive_regulation (induction) of CYP1A2
17) Confidence 0.47 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 1949032 Disease Relevance 0 Pain Relevance 0.12
These data are consistent with the hypothesis that omeprazole is generally devoid of inducing effects on CYP1A2 activity in vivo, at least in a Caucasian population with a low prevalence of the omeprazole-mephenytoin poor metabolizer phenotype.
Positive_regulation (inducing) of CYP1A2
18) Confidence 0.46 Published 1994 Journal Ther Drug Monit Section Abstract Doc Link 8085279 Disease Relevance 0 Pain Relevance 0.17
Collectively, BF has inducing potential of liver CYP1A2 and CYP2E1 and may influence the corresponding pharmacokinetics of other drugs.
Positive_regulation (inducing) of CYP1A2 in liver
19) Confidence 0.44 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.05 Pain Relevance 0.09
CYP1A2, CYP2B1, CYP2C6, CYP2C7, CYP3A, and CYP4A1 were all induced by pethidine treatment, whereas CYP2C11 and CYP2E1 were unchanged.
Positive_regulation (induced) of CYP1A2 associated with algil
20) Confidence 0.41 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7838134 Disease Relevance 0 Pain Relevance 0.79

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