INT178674

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.05
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (RNGTT) nucleoplasm (RNGTT) nucleus (RNGTT)
nucleotidyltransferase activity (RNGTT)
Anatomy Link Frequency
THP-1 1
T cells 1
RNGTT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 109 97.92 Very High Very High Very High
Inflammation 104 95.12 Very High Very High Very High
dexamethasone 43 93.24 High High
chemokine 35 71.28 Quite High
agonist 17 50.00 Quite Low
addiction 1 38.00 Quite Low
aspirin 3 32.08 Quite Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 100 96.08 Very High Very High Very High
Sprains And Strains 3 95.76 Very High Very High Very High
INFLAMMATION 116 95.12 Very High Very High Very High
Lower Respiratory Tract Infection 9 70.48 Quite High
Infection 54 67.32 Quite High
Apoptosis 66 50.00 Quite Low
Ocular & Orbital Inflammation 2 50.00 Quite Low
Death 28 40.96 Quite Low
Stress 27 5.00 Very Low Very Low Very Low
Disorders Of The Lacrimal System 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the time when UV-B treated HCE-T cells were collected for RNA isolation (6 h or 24 h after UV-B irradiation), cell culture supernatants were harvested, centrifuged, and stored at ?
Positive_regulation (treated) of HCE in T cells
1) Confidence 0.15 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.18
However, procaspase-1 was clearly detectable at the protein level in HCE-T cells, while no sign of its activation was observed, as also seen in unstimulated THP-1 cells (Figure 2C).
Positive_regulation (activation) of HCE in THP-1
2) Confidence 0.14 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
Twenty-four hours after UVB irradiation, HCE cell culture supernatants were harvested, centrifuged, and stored at ?
Positive_regulation (supernatants) of HCE
3) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0 Pain Relevance 0.14
Twenty-four hours after UVB irradiation, HCE cell culture supernatants were harvested, centrifuged, and stored at ?
Positive_regulation (supernatants) of HCE
4) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0 Pain Relevance 0
These results are in agreement with a role of viral macromolecular synthesis in the activation of these signaling pathways in HCE cells.
Positive_regulation (activation) of HCE
5) Confidence 0.03 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 0.90 Pain Relevance 0.15
BOL-303242-X reduces MAPK phosphorylation/activation in HCEpiCs
Positive_regulation (activation) of HCEpiCs
6) Confidence 0.00 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.16 Pain Relevance 0.62

General Comments

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