INT178751

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 51
Total Number 52
Disease Relevance 1.47
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (TMPO) chromosome (TMPO) nucleus (TMPO)
DNA binding (TMPO)
Anatomy Link Frequency
tail 1
TMPO (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3309 99.98 Very High Very High Very High
b2 receptor 37 65.16 Quite High
bradykinin 37 58.76 Quite High
imagery 26 52.92 Quite High
antagonist 17 17.60 Low Low
Angina 50 5.00 Very Low Very Low Very Low
COX2 37 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 52 97.92 Very High Very High Very High
Injury 37 96.72 Very High Very High Very High
Trepenoma Infection 111 89.36 High High
Hypertension 126 85.04 High High
Thrombosis 113 83.56 Quite High
Increased Venous Pressure Under Development 124 75.92 Quite High
Atherosclerosis 39 60.16 Quite High
Disease 47 50.00 Quite Low
Stress 113 42.56 Quite Low
Muscular Spasm 13 41.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 10µl sample was tested in duplicate using a real-time PCR that targets the DNA polymerase I gene of Tp (polA).
Positive_regulation (targets) of Tp
1) Confidence 0.44 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2872645 Disease Relevance 0.09 Pain Relevance 0
also mediated rapid RhoA activation in HEK.TP?
Positive_regulation (activation) of TP
2) Confidence 0.27 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Consistent with their reduced expression in the 1° h.AoSMCs, there was a significant reduction in U46619-mediated Rho activation and cofilin phosphorylation in the presence of RNAi directed to either TP?
Positive_regulation (directed) of TP
3) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0
Moreover, pre-incubation of HEK.TP?
Positive_regulation (incubation) of TP
4) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.21 Pain Relevance 0
expression following 72 h incubation of HEK.TP?
Positive_regulation (incubation) of TP
5) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.28 Pain Relevance 0
cells but neither agent affected such responses in HEK.TP?
Positive_regulation (responses) of TP
6) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
However, as stated, our data generated in the HEK 293 cell lines over-expressing the individual TP?
Positive_regulation (individual) of TP
7) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.08
remains unaffected by either agent, at the interface of the receptor at least, the functional role of TP?
Positive_regulation (role) of TP
8) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.13 Pain Relevance 0
cells were treated according to the latter conditions but using TP?
Positive_regulation (using) of TP
9) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
and its specific site directed variants TP?
Positive_regulation (variants) of TP
10) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
independently or indeed differentially modulate RhoA activation and downstream signaling, there is substantial evidence that the TP?
Positive_regulation (activation) of TP
11) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.18 Pain Relevance 0.04
significantly impaired U46619-induced RhoA activation in HEK.TP?
Positive_regulation (activation) of TP
12) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.19 Pain Relevance 0
More specifically, by directly targeting TP?
Positive_regulation (targeting) of TP
13) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
independently regulated RhoA activation and signaling in clonal cells over-expressing TP?
Positive_regulation (activation) of TP
14) Confidence 0.18 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
The level of response at the third plateau, TP, is only dependent on four of the system constants, viz. a, b, d, and the isomerization constant L, and is thus independent of parameters AS, AM, and c.
Positive_regulation (dependent) of TP
15) Confidence 0.08 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0
Consistent with this, while stimulation of HEK.TP?
Positive_regulation (stimulation) of TP
16) Confidence 0.06 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.15
Moreover, pre-incubation with KT 5823 reduced the level of agonist-induced TP?
Positive_regulation (induced) of TP associated with agonist
17) Confidence 0.06 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.20
Hence, Ala-scanning and/or deletion mutagenesis was used to systematically disrupt those putative phospho-targets either individually, to generate TP?
Positive_regulation (generate) of TP
18) Confidence 0.06 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
Thus, Ala-scanning and/or deletion mutagenesis was used to disrupt those putative phospho-targets either individually to generate TP?
Positive_regulation (generate) of TP
19) Confidence 0.06 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.07
Stimulation of HEK.TP?
Positive_regulation (Stimulation) of TP
20) Confidence 0.06 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.10

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