INT178752

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.58
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
Anatomy Link Frequency
plasma 2
liver 1
appendix 1
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 129 98.28 Very High Very High Very High
rheumatoid arthritis 77 89.84 High High
fibrosis 46 80.08 Quite High
Glutamate receptor 4 76.96 Quite High
tolerance 7 71.08 Quite High
antagonist 18 53.04 Quite High
Glutamate 4 42.24 Quite Low
Inflammation 20 5.00 Very Low Very Low Very Low
alcohol 19 5.00 Very Low Very Low Very Low
Somatostatin 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acromegaly 83 98.40 Very High Very High Very High
Diabetes Mellitus 15 96.84 Very High Very High Very High
Insulin Resistance 11 94.24 High High
Fibrosis 47 91.76 High High
Rheumatoid Arthritis 77 89.84 High High
Fatty Liver 56 89.32 High High
Hepatitis 43 86.80 High High
Nash(non-alcoholic Steatohepatitis) 186 83.12 Quite High
Obesity 22 75.52 Quite High
Disease 39 71.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin is covalently bound to A2M [42] in plasma and A2M is a binding protein of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) which modifies the IGFBP-1/IGF interaction [43].
IGFBP-1 Binding (binding) of in plasma
1) Confidence 0.15 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.69 Pain Relevance 0.04
Insulin is covalently bound to A2M [42] in plasma and A2M is a binding protein of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) which modifies the IGFBP-1/IGF interaction [43].
IGFBP-1 Binding (interaction) of in plasma
2) Confidence 0.14 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.74 Pain Relevance 0.04
IGFBP-1, which is also derived from the liver, binds to free IGF-I and is negatively regulated by nutrition and insulin [20].
IGFBP-1 Binding (binds) of in liver
3) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.55 Pain Relevance 0.15
The concentration of IGFBP3, the main IGF carrier protein, is usually increased in patients with acromegaly, but this marker offers little further diagnostic information.


IGF carrier protein Binding (concentration) of associated with acromegaly
4) Confidence 0.03 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 0.60 Pain Relevance 0.04
For the HOTSM it is a bit more complex, as a single ligand can interact with two binding sites.
binding Binding (interact) of
5) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0.10
Meanwhile, when a heterotropic ligand, that is known to interact with a non-primary binding site, reduces the receptor response, such a reduction in spontaneous activity may be referred to as "inverse allosteric agonism".
binding Binding (interact) of
6) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0.16
In the cyclic-two-state model, cTSM, discussed in section 2 of the appendix, inverse agonists are defined as ligands that have an intrinsic efficacy parameter a less than 1, when interacting with the primary binding site [55].
binding Binding (interacting) of in appendix associated with agonist
7) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0.09
A second level of activity is found in the mid range of ligand concentrations, where ligands associate with the two binding sites to form in particular R*S and SR*.
binding Binding (associate) of
8) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0

General Comments

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